Table 3 Performance of HPV16/18 genotyping, cytology, and S5 methylation for detecting (His)HSIL+
Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | |
|---|---|---|---|---|
HPV16/18+ | 64.4 (57.8–72.1) | 44.9 (40.5–49.1) | 74.6 (71.3–76.8) | 33.3 (29.3–38.2) |
Cytology ≥(TCT)HSIL+ | 48.9 (42.8–53.2) | 54.4 (50.3–58.4) | 73.1 (70.5–75.9) | 29.7 (25.4–34.8) |
S5 cutoff 2.85 | 89.1 (86.2–92.4) | 76.6 (72.2–78.9) | 90.6 (87.2–93.1) | 73.5 (69.6–75.7) |
S5 cutoff 0.8 | 98.3 (94.8–99.2) | 20.9 (17.1–25.8) | 75.8 (70.0–81.4) | 85.7 (80.7–89.3) |
S5 cutoff 3.7 | 77.9 (72.5–83.9) | 80.2 (76.1–85.0) | 90.8 (86.6–94.3) | 59.0 (55.9–63.7) |