Fig. 3
From: The signature of HBV-related liver disease in peripheral blood mononuclear cell DNA methylation
Biomarker CpG sites selection using hierarchical clustering and LASSO-regularized regression. a Hierarchical clustering analysis consisting of nine differentially CpG sites in PBMC DNA from 48 liver disease patients. b Representative repetition of five-fold CV LASSO coefficients of nine candidate CpG sites. The first vertical dotted line corresponds to the λmin that minimized binomial deviance during CV. The second dotted line corresponds to λ1se (0.051), used for the selection of biomarker CpG sites. c LASSO coefficient profile plot of the coefficient paths. Nine CpG sites had their coefficients significantly different from zero