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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern

Fig. 2

Differentially methylated position analysis in adipose-derived stem cells isolated from patients with Crohn’s disease and healthy controls. a Intragenic differentially methylated position (DMP) distribution: approximately 45% of the DMPs are located in the gene body and 35% are located in the promoter. CpG allocation: > 50% of the CpGs are in the open sea region. b Distribution of hypo- and hypermethylated DMPs for Crohn’s-hASC and control-hASCs. c Heatmap and hierarchical clustering of CpGs according to their methylation profile in Crohn’s disease patients compared with healthy donors. Red bars represent hypomethylated positions and yellow bars hypermethylated positions. d Principal component analysis demonstrating the first two main components of the significant CpG data set. e Manhattan plot of all DMPs. Significant DMPs are colored in green, achieving the significance threshold (p < 0.0001). f Volcano plot showing the top DMPs associated with genes. Visualization of the genes with the highest number of significant CpGs. Negative values (points to the left of the graph) indicate hypomethylated; positive values (points to the right of the graph) indicate hypermethylated. ExonBnd, exon boundaries; UTR, untranslated region; TSS, transcription start site; hASCs, human adipose-stem cells

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