From: DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes
 | Pan-tissue | Skin & Blood | PhenoAge | GrimAge | ||||
---|---|---|---|---|---|---|---|---|
Factor | Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | Beta (SE) | p |
Sex (male) | 1.47 (0.44) | 8.00E−4 | − 0.42 (0.32) | 0.18 | − 1.50 (0.53) | 4.57E−3 | 1.45 (0.37) | 9.99E−5 |
Cohort (primary) | − 0.27 (0.58) | 0.64 | − 0.14 (0.42) | 0.74 | 0.82 (0.69) | 0.24 | − 0.71 (0.49) | 0.15 |
Age (years) | 0.85 (0.03) | 1.16E−86 | 1.06 (0.02) | 3.48E−160 | 0.94 (0.04) | 2.39E−77 | 0.80 (0.03) | 2.21E−99 |
T1D Duration (months) | 0.009 (0.005) | 0.06 | 0.003 (0.004) | 0.43 | 0.01 (0.01) | 4.29E−2 | − 0.005 (0.004) | 0.24 |
Stimulated C-peptide (pmol/ml) | − 0.15 (1.79) | 0.93 | − 0.72 (1.30) | 0.58 | − 1.74 (2.15) | 0.42 | − 2.05 (1.51) | 0.18 |
Time-weighted HbA1c (%)* | 0.05 (0.14) | 0.71 | − 0.01 (0.10) | 0.89 | 0.38 (0.17) | 2.57E−2 | 0.02 (0.12) | 0.86 |
BMI (kg/m2) | 0.02 (0.06) | 0.76 | 0.09 (0.04) | 4.84E−2 | 0.09 (0.07) | 0.20 | − 0.02 (0.05) | 0.72 |
Systolic blood pressure (mmHg) | − 0.01 (0.02) | 0.66 | 0.004 (0.017) | 0.79 | − 0.03 (0.03) | 0.33 | − 0.01 (0.02) | 0.48 |
Diastolic blood pressure (mmHg) | 0.01 (0.03) | 0.75 | − 0.01 (0.02) | 0.53 | 0.005 (0.038) | 0.90 | 0.01 (0.03) | 0.83 |
HDL (mg/dl) | 0.93 (0.65) | 0.15 | 0.01 (0.47) | 0.98 | 0.59 (0.78) | 0.45 | − 0.11 (0.55) | 0.85 |
LDL (mg/dl) | 0.91 (0.65) | 0.16 | 0.02 (0.47) | 0.96 | 0.60 (0.78) | 0.45 | − 0.09 (0.55) | 0.87 |
Triglyceride (mg/dl) | 0.18 (0.13) | 0.16 | 0.001 (0.094) | 0.99 | 0.11 (0.16) | 0.48 | − 0.02 (0.11) | 0.85 |
Total cholesterol (mg/dl) | − 0.91 (0.65) | 0.16 | − 0.02 (0.47) | 0.97 | − 0.58 (0.78) | 0.46 | 0.10 (0.55) | 0.85 |
Pulse rate (beat/min) | − 0.01 (0.02) | 0.65 | 0.01 (0.02) | 0.38 | 0.01 (0.03) | 0.75 | 0.01 (0.02) | 0.67 |
Current smoker vs. non-smoker | − 0.16 (0.50) | 0.76 | − 0.51 (0.36) | 0.16 | 0.99 (0.60) | 0.10 | 7.13 (0.42) | 9.03E−50 |
Regular drinker vs. non-drinker | − 0.37 (0.46) | 0.42 | 0.26 (0.33) | 0.43 | 0.38 (0.55) | 0.49 | 0.69 (0.38) | 0.07 |
Occasional drinker vs. non-drinker | − 0.66 (0.67) | 0.32 | − 0.50 (0.49) | 0.30 | 0.41 (0.81) | 0.61 | 0.71 (0.57) | 0.21 |
Strenuous activity vs. sedentary†| − 1.99 (0.99) | 4.53E−2 | − 0.85 (0.72) | 0.24 | − 0.94 (1.20) | 0.43 | 0.54 (0.84) | 0.52 |
Moderate activity vs. sedentary†| − 0.11 (0.39) | 0.78 | 0.23 (0.28) | 0.41 | 0.05 (0.47) | 0.91 | 0.25 (0.33) | 0.44 |
METS > 1500 vs. METs < 450‡ | − 0.18 (0.47) | 0.71 | − 0.27 (0.34) | 0.42 | 0.60 (0.57) | 0.29 | − 0.33 (0.40) | 0.41 |
METs 450–1500 vs. METs < 450‡ | − 0.56 (0.48) | 0.25 | − 0.81 (0.35) | 2.15E−2 | − 0.56 (0.58) | 0.34 | − 0.76 (0.41) | 0.06 |