Skip to main content

Table 6 Combination index (CI) values for treatments with combined MAKV-8-imatinib in imatinib-sensitive and imatinib-resistant CML cells

From: Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

Cell line

MAKV-8 (μM)

Imatinib (μM)

CI (48 h)a

K-562

5

0.25

0.42 ± 0.13

10

0.25

0.28 ± 0.14

KBM-5

1

2.5

0.46 ± 0.06

2.5

2.5

0.05 ± 0.03

MEG-01

5

0.25

0.77 ± 0.16

10

0.25

0.37 ± 0.07

KBM-5R

1

10

1.42 ± 0.58

2.5

10

0.78 ± 0.16

  1. aCI values correspond to the mean ± standard deviation of three independent Hoechst-propidium iodide staining experiments
  2. CML chronic myeloid leukemia
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us