Genome-wide analysis of constitutional DNA methylation in familial melanoma

Clinical Epigenetics

Table 2 Methylation levels (Δβ value) in all 6 significant upregulated CpGs in all subjects (n = 10)

CpG ID	Gene ID	BIOS control cases	Family I		Family II		Family III		Family IV		Family V
		BIOS control cases	I_1	I_2	II_1	II_2	III_1	III_2	IV_1	IV_2	V_1	V_2
		β value^a	Δβ value^b
cg21812670	RABGGTB	0.06	0.30	0.38	0.34	0.30	0.36	0.26	0.39	0.32	0.39	0.30
cg26642667	SND1	0.06	0.25	0.30	0.33	0.22	0.35	0.16	0.37	0.29	0.34	0.27
cg04385631	SCAF11	0.02	0.14	0.00	0.00	0.22	0.00	0.22	0.23	0.00	0.22	0.28
cg21843755	ZNF638	0.11	0.16	0.21	0.18	0.07	0.20	0.10	0.21	0.16	0.23	0.21
cg03301282	THAP1	0.08	0.26	0.23	0.20	0.27	0.25	0.12	0.29	0.27	0.30	0.24
cg02470959	SFSWAP	0.05	0.18	0.20	0.18	0.16	0.19	0.17	0.21	0.21	0.20	0.17

^aRepresents the average β value for the 1000 BIOS controls at each CpG site
^bRepresents the difference between BIOS average β value and patient β value at each CpG site

ISSN: 1868-7083