Epigenetic predictors of all-cause mortality are associated with objective measures of neighborhood disadvantage in an urban population

Table 3 Association between PC7 and components of the eMRS

	Beta	P value	95% CI	Chr	Gene
cg08362785	0.01	4.0 × 10⁻⁴	0.006, 0.02	22	MKL1
cg01612140	− 0.03	4.5 × 10⁻⁴	− 0.04, − 0.01	6
cg23665802	− 0.02	0.001	− 0.03, − 0.008	13	MIR19A
cg24704287	− 0.02	0.002	− 0.03, − 0.007	19
cg25983901	− 0.01	0.02	− 0.02, − 0.003	7
cg10321156	− 0.01	0.02	− 0.03, − 0.002	11
cg19572487	0.01	0.23	− 0.005, 0.02	17	RARA
cg06126421	− 0.01	0.26	− 0.03, 0.007	6
cg14975410	− 0.002	0.70	− 0.02, 0.01	3
cg05575921	0.001	0.88	− 0.02, 0.02	5	AHRR

Multiple DNA methylation loci (CpG) which composed the epigenetic mortality risk score (eMRS) even after a multiple test correction for the 10 tests performed (P < 0.005). Chromosome and associated gene were taken from the Illumina 450K manifest file. Gene annotation is by proximity. CI confidence interval; Chr chromosome

ISSN: 1868-7083