Fig. 4

Spearman correlations between HIV-1 proviral DNA methylation and patient characteristics. a Correlation of DNA methylation with several virological and viral reservoir markers in HIV-1-infected individuals. Positive and negative correlations are depicted in red and blue, respectively. Non-significant correlations are left blank. Correlations with covariates that independently explained methylation in the linear regression models are depicted with a black frame. b Correlation plots between DNA methylation (M value) and the independent variables from the linear models. Upper left, LTR methylation vs. duration of VL suppression. Upper right, env methylation vs. log VL. Lower left, env methylation vs. CD4 nadir. Lower right, env methylation vs. CD4 count