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Table 7 Sensitivity, Specificity, PPV, and NPV at optimal cutoffs with AUC regarding tumor size (0–1 cm)

From: Ultrasensitive DNA hypermethylation detection using plasma for early detection of NSCLC: a study in Chinese patients with very small nodules

Gene

Sensitivity

Specificity

PPV

NPV

AUC

95% CI

CDO1

82%

46%

66%

67%

0.64

0.49–0.80

TAC1

61%

78%

78%

61%

0.68

0.56–0.81

SOX17

61%

77%

77%

61%

0.68

0.56–0.80

HOXA7

82%

59%

72%

72%

0.73

0.60–0.87

CDO1, TAC1, SOX17

71%

82%

83%

69%

0.81

0.69–0.93

CDO1, SOX17, HOXA7

64%

82%

82%

64%

0.75

0.62–0.89

  1. Cancer, n = 28; control, n = 22