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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Replication and expansion of epigenome-wide association literature in a black South African population

Fig. 4

% Methylation change per centimetre change in WC. From left to right: (i) reference EA vs. AA data, (ii) AA vs. PURE-SA-NW data and (iii) EA vs. PURE-SA-NW data. WC was normalised to have a mean of 0 and a standard deviation of 1. Model used for PURE-SA-NW EWAS: methylation ~ WC + age + alcohol consumption + smoking + physical activity + education + cell counts + surrogate variables. Reference data: Demerath et al. (2015). Green data points represent CpGs where the 95% CIs for effect size estimates in each sample group overlap. Yellow data points represent CpGs where the 95% CIs for effect size estimates in each sample group do not overlap. Red data points represent the comparison of effect sizes within the reference cohorts. Black dashed line: line of equality. Blue dashed line: regression line

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Clinical Epigenetics

ISSN: 1868-7083

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