Clinical Epigenetics

Table 3 Associations of 22 adult non-alcoholic fatty liver disease-associated CpGs with liver fat fraction in children

From: Newborn and childhood differential DNA methylation and liver fat in school-age children

				Newborns			Children
CpG	Chromosome	Position	Gene	Effect^*	SE^*	P value	Effect^*	SE^*	P value
cg09469355	1	2161886	SKI	0.002	0.03	0.96	− 0.002	0.07	0.98
cg17901584	1	55353706	DHCR24	− 0.005	0.02	0.74	− 0.069	0.04	0.08
cg03725309	1	109757585	SARS	− 0.012	0.02	0.45	0.027	0.05	0.56
cg14476101	1	120255992	PHGDH	− 0.003	0.02	0.99	0.011	0.04	0.78
cg19693031	1	145441552	TXNIP	− 0.011	0.03	0.72	− 0.031	0.04	0.45
cg06690548	4	139162808	SLC7A11	− 0.086	0.05	0.08	− 0.027	0.06	0.67
cg05119988	4	166251189	SC4MOL	0.003	0.02	0.88	0.003	0.03	0.92
cg03957124	6	37016869	COX6A1P2^**	0.011	0.02	0.59	0.027	0.05	0.58
cg18120259	6	43894639	LOC100132354^**	0.024	0.02	0.31	− 0.124	0.05	0.02
cg17501210	6	166970252	RPS6KA2	0.086	0.07	0.21	− 0.137	0.08	0.10
cg21429551	7	30635762	GARS	0.015	0.02	0.42	0.017	0.03	0.52
cg11376147	11	57261198	SLC43A1	− 0.004	0.03	0.89	0.107	0.07	0.11
cg00574958	11	68607622	CPT1A	0.028	0.04	0.43	− 0.019	0.08	0.79
cg26894079	11	122954435	ASAM	0.004	0.03	0.88	− 0.020	0.04	0.63
cg11024682	17	17730094	SREBF1	− 0.023	0.04	0.54	− 0.005	0.07	0.93
cg14020176	17	72764985	SLC9A3R1	0.006	0.03	0.84	− 0.007	0.06	0.90
cg19016694	17	80821826	TBCD	0.016	0.03	0.55	− 0.062	0.06	0.30
cg15860624	19	3811194	ZFR2	0.011	0.02	0.61	0.002	0.05	0.97
cg02711608	19	47287964	SLC1A5	− 0.025	0.03	0.44	0.004	0.06	0.95
cg08309687	21	35320596	LINC00649^**	− 0.004	0.03	0.88	− 0.008	0.04	0.84
cg27243685	21	43642366	ABCG1	0.042	0.04	0.32	− 0.023	0.09	0.81
cg06500161	21	43656587	ABCG1	0.018	0.03	0.57	0.023	0.05	0.66

^*Effect estimates represent the change in liver fat fraction (%) per 10% difference in DNA methylation beta and standard error. Associations are adjusted for maternal age, education level, early-pregnancy BMI and smoking, age at birth or child age at measurement, child sex, cell type proportions, and batch. ^*Gene names added using information from the UCSC Genome Browser build hg19. Other gene names from original paper by Ma et al. 2019. BMI body mass index, n number, SE standard error

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