Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder

Table 2 Differentially methylated positions (DMPs) in MRS, Army STARRS, and PRISMO

Probe	Chr: position	Gene	Region	MRS			Army STARRS			Stage 1: MRS and Army STARRS		Stage 1: replication in PRISMO			Stage 2: meta-analysis of 3 cohorts
Probe	Chr: position	Gene	Region	β	SE	p value	β	SE	p value	Z	p value	β	SE	p value	Z	p value
cg05656210	5: 141660565	Intergenic	Intergenic	− 0.37	0.15	1.6E−02	− 0.58	0.09	6.1E−10	− 5.73	1.0E−08	− 0.47	0.20	2.0E−02*	− 6.14	8.1E−10
cg12169700	7: 1923695	MAD1L1	Body	− 1.24	0.27	4.2E−06	− 0.19	0.20	3.3E−01	− 4.22	2.4E−05	− 0.64	0.14	4.3E−06	− 5.91	3.3E−09
cg20756026	17: 80394529	HEXDC	Body	− 0.62	0.21	3.3E−03	− 0.28	0.09	2.6E−03	− 4.17	3.0E−05	− 0.37	0.09	2.6E−05	− 5.69	1.3E−08
cg16956686	7: 4304779	SDK1	Body	− 0.19	0.04	3.6E−07	− 0.13	0.05	7.1E−03	− 5.67	1.5E−08	− 0.04	0.09	6.3E−01	− 5.20	2.0E−07
cg18917957	1: 15764093	CTRC	TSS1500	− 0.34	0.08	2.3E−05	− 0.26	0.08	4.9E−04	− 5.48	4.2E−08	− 0.06	0.13	6.4E−01	− 5.03	5.0E−07
cg05901543	16: 89251975	CDH15	Body	− 0.14	0.03	2.4E−08	− 0.06	0.03	7.1E−02	− 5.50	3.7E−08	0.01	0.05	8.2E−01	− 4.71	2.5E−06

SE standard error. All positions and regions were in reference to GRCh37/hg19. Significance (p < 1.13 × 10⁻⁷) is indicated in italics. The asterisk indicates significance of replication after the Bonferroni correction for four probes (one-sided z test). The p values for MRS, Army STARRS, and the combined analyses are Bonferroni-corrected for ~ 450K CpG sites. In stage 1, MRS and Army STARRS were combined and PRISMO was used to replicate significant findings. In stage 2, all three studies were combined. The table is organized based on significances of the DMPs in the stage 2 meta-analysis

ISSN: 1868-7083