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Table 2 Number of significant differentially methylated CpG sites before and after the surgery before and after adjustment for clinical variables (n = 30).

From: The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients

Model

Number of Bonferroni corrected significant CpG sites (% decrease from model 1)

Model 1 (adjusted for cell type distribution)

3649

Model 1 + BMI

1813 (51%)

Model 1 + insulin

1686 (54%)

Model 1 + CRP

3294 (10%)

Model 1 + glucose

3415 (6%)

Model 1 + BMI+ insulin + CRP + glucose

1386 (62%)