Overall and sex-specific associations between methylation of the ABCG1 and APOE genes and ischemic stroke or other atherosclerosis-related traits in a sibling study of Chinese population

Table 2 Associations between DNA methylation in ABCG1 and APOE and risk of ischemic stroke

	OR	95% CI	P value
cg02494239
Above vs below median	2.416	1.024–5.700	0.044
Q₂ vs Q₁	1.636	0.439–6.091	0.463
Q₃ vs Q₁	2.151	0.654–7.076	0.207
Q₄ vs Q₁	4.461	1.226–16.225	0.023
10% increasing of methylation level	1.254	0.875–1.795	0.217
cg06500161
Above vs below median	0.846	0.357–2.000	0.703
Q₂ vs Q₁	0.641	0.183–2.243	0.486
Q₃ vs Q₁	0.509	0.155–1.667	0.264
Q₄ vs Q₁	1.000	0.291–3.441	1.000
10% increasing of methylation level	1.054	0.386–2.881	0.918
cg14123992
Above vs below median	1.347	0.552–3.286	0.512
Q₂ vs Q₁	0.911	0.249–3.336	0.889
Q₃ vs Q₁	0.864	0.236–3.169	0.826
Q₄ vs Q₁	1.967	0.521–7.429	0.319
10% increasing of methylation level	0.921	0.297–2.852	0.886

Categorical variable for each CpG sites was defined using the 25% quartile, the median, and the 75% quartile of the methylation value, where Q₁ group was 0–25% of the values, Q₂ was 25–50%, Q₃ was 50–75%, and Q₄ was 75–100%. ABCG1 ATP–binding cassette G1 gene, APOE apolipoprotein E gene, OR odds ratio, 95% CI 95% confidence interval

ISSN: 1868-7083