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Table 1 Characteristics of the study population according to ischemic stroke status

From: Overall and sex-specific associations between methylation of the ABCG1 and APOE genes and ischemic stroke or other atherosclerosis-related traits in a sibling study of Chinese population

Variables

Proband

(Ischemic stroke cases, n = 55)

Sibling

(ischemic stroke-free controls, n = 55)

P value

Age (years), mean (SD)

60.055 (7.578)

59.655 (8.044)

0.262

Male (%)

37 (67.273)

30 (54.545)

0.127

Primary school or higher (%)

27 (51.923)

25 (48.077)

0.683

Marriage (%)

47 (90.385)

48 (92.308)

0.564

Smoking (%)

31 (59.615)

30 (57.692)

0.808

Drinking (%)

27 (52.941)

25 (49.020)

0.637

Diabetes (%)

20 (36.363)

11 (20.000)

0.020

Hypertension (%)

48 (87.273)

41 (74.545)

0.071

TC (mmol/L) *

3.080 (2.160–3.910)

3.175 (2.270–3.720)

0.850

TG (mmol/L) *

1.190 (0.770–1.950)

1.095 (0.770–1.930)

0.294

HDL (mmol/L) *

0.880 (0.670–1.040)

0.840 (0.680–1.120)

0.973

LDL (mmol/L) *

2.050 (1.340–2.930)

1.920 (1.510–2.680)

0.806

BMI (kg/m2), mean (SD)

26.531 (3.527)

26.309 (3.655)

0.694

baPWV (cm/s), mean (SD)

1779.679 (344.664)

1710.604 (328.646)

0.230

cIMT (mm), mean (SD)

0.743 (0.122)

0.695 (0.084)

0.002

ABI, mean (SD)

1.052 (0.140)

1.112 (0.087)

0.004

Methylation level (%)

 cg02494239 (ABCG1)

  Mean (SD)

89.835 (10.900)

88.236 (12.916)

0.111

  Median (interquartile range)

93.660 (92.780–94.240)

93.260 (92.210–93.780)

0.022

  Range (minimum–maximum)

46.860–95.930

40.180–95.220

 

 cg06500161 (ABCG1)

  Mean (SD)

87.891 (4.261)

87.245 (4.364)

0.292

  Median (IQR)

88.475 (85.470–91.270)

88.325 (85.330–89.590)

0.436

  Range (minimum–maximum)

76.460–96.040

70.080–95.635

 

 cg14123992 (APOE)

  Mean (SD)

83.177 (4.491)

82.824 (2.787)

0.635

  Median (IQR)

84.200 (82.12–85.19)

83.530 (81.760–85.000)

0.105

  Range (minimum–maximum)

54.450–86.660

73.140–86.400

 
  1. TC total cholesterol, TG triglyceride, HDL high-density lipoprotein, LDL low-density lipoprotein, BMI body mass index, ABI ankle–brachial index, baPWV brachial–ankle pulse wave velocity, cIMT carotid intima–media thickness, ABI ankle–brachial index, ABCG1 ATP–binding cassette G1 gene, APOE apolipoprotein E gene, SD standard deviation, IQR interquartile range
  2. *These quantitative variables are given as the median (interquartile range) because of their skewed distribution