Fig. 2

Association of DNA methylation at ABCG1 and APOE and risk of atherosclerosis (cIMT, ABI, and baPWV). For a detailed analysis, methylation variable was presented as three types of variables for each CpG site, which were binary variable (above vs below median), categorical variable and continuous variable (10% increasing of methylation level). Categorical variable for each CpG sites was defined using the 25% quartile, the median, and the 75% quartile of the methylation value, where Q₁ group was 0–25% of the values, Q₂ was 25–50%, Q₃ was 50–75%, and Q₄ was 75–100%. β, regression coefficient; 95% CI, 95% confidence interval; ABCG1, ATP–binding cassette G1 gene; APOE, apolipoprotein E gene; cIMT, carotid intima–media thickness; ABI, ankle–brachial index; baPWV, brachial–ankle pulse wave velocity