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Table 3 Analysis of the effect of pubertal exposures on dynamic CpG sites replicated in ALSPAC

From: Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures

Pubertal exposures

CpG sites

Genes

Est. coeff.

p valueRaw

p valueAdj.

BMI10

BMI10 × gender$

cg08770870

RPH3AL

0.060

1.78 × 10−6

0.018

cg19663246

PDE1C

0.038

3.86 × 10−6

0.020

BMI10

cg08770870

RPH3AL

− 0.016

0.013

0.457

cg19663246

PDE1C

0.002

0.70

0.945

Pubertal events

Age growth spurt

cg08134671

GNG7

− 0.059

7.15 × 10−7

0.007

Female’s age of menarche

cg06271237

PLAGL1

− 0.028

7.91 × 10−6

0.081

Other pubertal exposures

Non-steroidal drugs

cg16384862

CWC15;

KDM4D

− 0.161

1.23 × 10−7

0.001

cg18552620

STK17A

− 0.206

1.66 × 10−7

0.001

cg12170787

SBNO2

− 0.014

7.60 × 10−6

0.026

cg00620824

HLA-C

− 0.029

3.93 × 10−5

0.080

cg12054453

TMEM49

− 0.035

3.93 × 10−5

0.080

cg11001739

MAD1L1

0.029

5.27 × 10−5

0.090

Do you currently smoke (yes)

cg05575921

AHRR

− 0.742

1.0 × 10−13

3.40 × 10−10

cg14753356

IER3

− 0.193

1.0 × 10−13

3.40 × 10−10

cg26703534

AHRR

− 0.178

1.0 × 10−13

3.40 × 10−10

cg24296397

BSN

0.094

7.25 × 10−7

0.002

cg08709672

AVPR1B

− 0.098

1.09 × 10−6

0.002

cg16391678

ITGAL

− 0.115

8.57 × 10−6

0.015

cg20295214

AVPR1B

− 0.117

1.55 × 10−5

0.023

cg21241889

TRAF1

− 0.070

2.36 × 10−5

0.030

cg04885881

SRM

− 0.092

3.99 × 10−5

0.045

cg08109568

FAN1

− 0.170

7.43 × 10−5

0.071

cg08884752

SKI

− 0.078

7.63 × 10−5

0.071

  1. [1] $Female is the reference group [2]. Est. coeff.: estimated regression coefficients for each risk factor [3]. p valueRaw: raw p values for each test [4]. p valueAdj: FDR-adjusted p values, and FDR-adjusted p values < 0.05 were in bold font. CpGs with FDR-adjusted p values < 0.1 were also included