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Table 3 Analysis of the effect of pubertal exposures on dynamic CpG sites replicated in ALSPAC

From: Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures

Pubertal exposuresCpG sitesGenesEst. coeff.p valueRawp valueAdj.
BMI10BMI10 × gender$cg08770870RPH3AL0.0601.78 × 1060.018
cg19663246PDE1C0.0383.86 × 1060.020
BMI10cg08770870RPH3AL− 0.0160.0130.457
cg19663246PDE1C0.0020.700.945
Pubertal eventsAge growth spurtcg08134671GNG7− 0.0597.15 × 1070.007
Female’s age of menarchecg06271237PLAGL1− 0.0287.91 × 10−60.081
Other pubertal exposuresNon-steroidal drugscg16384862CWC15;
KDM4D
− 0.1611.23 × 1070.001
cg18552620STK17A− 0.2061.66 × 1070.001
cg12170787SBNO2− 0.0147.60 × 1060.026
cg00620824HLA-C− 0.0293.93 × 10−50.080
cg12054453TMEM49− 0.0353.93 × 10−50.080
cg11001739MAD1L10.0295.27 × 10−50.090
Do you currently smoke (yes)cg05575921AHRR− 0.7421.0 × 10133.40 × 1010
cg14753356IER3− 0.1931.0 × 10133.40 × 1010
cg26703534AHRR− 0.1781.0 × 10133.40 × 1010
cg24296397BSN0.0947.25 × 1070.002
cg08709672AVPR1B− 0.0981.09 × 1060.002
cg16391678ITGAL− 0.1158.57 × 1060.015
cg20295214AVPR1B− 0.1171.55 × 1050.023
cg21241889TRAF1− 0.0702.36 × 1050.030
cg04885881SRM− 0.0923.99 × 1050.045
cg08109568FAN1− 0.1707.43 × 10−50.071
cg08884752SKI− 0.0787.63 × 10−50.071
  1. [1] $Female is the reference group [2]. Est. coeff.: estimated regression coefficients for each risk factor [3]. p valueRaw: raw p values for each test [4]. p valueAdj: FDR-adjusted p values, and FDR-adjusted p values < 0.05 were in bold font. CpGs with FDR-adjusted p values < 0.1 were also included