Table 3 Analysis of the effect of pubertal exposures on dynamic CpG sites replicated in ALSPAC
From: Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures
Pubertal exposures | CpG sites | Genes | Est. coeff. | p valueRaw | p valueAdj. | |
|---|---|---|---|---|---|---|
BMI10 | BMI10 × gender$ | cg08770870 | RPH3AL | 0.060 | 1.78 × 10−6 | 0.018 |
cg19663246 | PDE1C | 0.038 | 3.86 × 10−6 | 0.020 | ||
BMI10 | cg08770870 | RPH3AL | − 0.016 | 0.013 | 0.457 | |
cg19663246 | PDE1C | 0.002 | 0.70 | 0.945 | ||
Pubertal events | Age growth spurt | cg08134671 | GNG7 | − 0.059 | 7.15 × 10−7 | 0.007 |
Female’s age of menarche | cg06271237 | PLAGL1 | − 0.028 | 7.91 × 10−6 | 0.081 | |
Other pubertal exposures | Non-steroidal drugs | cg16384862 | CWC15; KDM4D | − 0.161 | 1.23 × 10−7 | 0.001 |
cg18552620 | STK17A | − 0.206 | 1.66 × 10−7 | 0.001 | ||
cg12170787 | SBNO2 | − 0.014 | 7.60 × 10−6 | 0.026 | ||
cg00620824 | HLA-C | − 0.029 | 3.93 × 10−5 | 0.080 | ||
cg12054453 | TMEM49 | − 0.035 | 3.93 × 10−5 | 0.080 | ||
cg11001739 | MAD1L1 | 0.029 | 5.27 × 10−5 | 0.090 | ||
Do you currently smoke (yes) | cg05575921 | AHRR | − 0.742 | 1.0 × 10−13 | 3.40 × 10−10 | |
cg14753356 | IER3 | − 0.193 | 1.0 × 10−13 | 3.40 × 10−10 | ||
cg26703534 | AHRR | − 0.178 | 1.0 × 10−13 | 3.40 × 10−10 | ||
cg24296397 | BSN | 0.094 | 7.25 × 10−7 | 0.002 | ||
cg08709672 | AVPR1B | − 0.098 | 1.09 × 10−6 | 0.002 | ||
cg16391678 | ITGAL | − 0.115 | 8.57 × 10−6 | 0.015 | ||
cg20295214 | AVPR1B | − 0.117 | 1.55 × 10−5 | 0.023 | ||
cg21241889 | TRAF1 | − 0.070 | 2.36 × 10−5 | 0.030 | ||
cg04885881 | SRM | − 0.092 | 3.99 × 10−5 | 0.045 | ||
cg08109568 | FAN1 | − 0.170 | 7.43 × 10−5 | 0.071 | ||
cg08884752 | SKI | − 0.078 | 7.63 × 10−5 | 0.071 | ||