Table 5 Combined DNA methylation at the CpG sites, − 689, − 659, and − 651 of the ANKRD26 promoter in relation to metabolic and inflammatory parameters. Relationships were assessed in lean and obese individuals by covariate-adjusted Spearman’s rank-order correlation adjusted for age. Number of individuals (n), correlation coefficient r, and age-adjusted p value are shown on the table. TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CRP, C-reactive protein; IL, interleukin; IFNγ, interferon γ; TNFα, tumor necrosis factor α; IP-10, interferon gamma-induced protein 10; MCP1, monocyte chemotactic protein 1; MIP1, macrophage inflammatory protein 1; RANTES, regulated on activation, normal T cell expressed, and secreted

From: Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity