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Table 5 Combined DNA methylation at the CpG sites, − 689, − 659, and − 651 of the ANKRD26 promoter in relation to metabolic and inflammatory parameters. Relationships were assessed in lean and obese individuals by covariate-adjusted Spearman’s rank-order correlation adjusted for age. Number of individuals (n), correlation coefficient r, and age-adjusted p value are shown on the table. TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CRP, C-reactive protein; IL, interleukin; IFNγ, interferon γ; TNFα, tumor necrosis factor α; IP-10, interferon gamma-induced protein 10; MCP1, monocyte chemotactic protein 1; MIP1, macrophage inflammatory protein 1; RANTES, regulated on activation, normal T cell expressed, and secreted

From: Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity

ParametersCombined % CpG methylation
nrp value
Glucose340.081n.s.
TG340.593< 0.001
TC340.155n.s.
HDL-C34− 0.5390.004
LDL-C340.3760.044
CRP340.5240.001
IL-1β300.242n.s.
IL-6300.5770.002
IL-7300.182n.s.
IL-9300.032n.s.
IL-12300.4530.013
IL-1730− 0.001n.s.
IFN-γ30− 0.025n.s.
TNF-α30− 0.083n.s.
IL-8300.6980.001
Eotaxin300.001n.s.
IP-10300.337n.s.
MCP-1300.305n.s.
MIP-1α300.3330.050
MIP-1β300.377n.s.
RANTES300.5140.013