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Table 2 Pro-inflammatory cytokine and chemokine features of lean (n = 12; 6 males and 6 females) and obese (n = 18; 9 males and 9 females) individuals. Data are shown as median (first quartile—Q1; third quartile—Q3) and statistical differences between the two groups were tested using Mann-Whitney U test. IL, interleukin; IFNγ, interferon γ; TNFα, tumor necrosis factor α; IP-10, interferon gamma-induced protein 10; MCP1, monocyte chemotactic protein 1; MIP1, macrophage inflammatory protein 1; RANTES, regulated on activation, normal T cell expressed, and secreted

From: Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity

 LeanObesep value
IL-1β (pg mL−1)3.1 (2.7; 3.4)3.4 (2.8; 4.5)n.s.
IL-6 (pg mL−1)4.1 (3.0; 5.3)8.6 (6.0; 11.1)< 0.001
IL-7 (pg mL−1)9.0 (7.9; 12.0)13.1 (8.8; 15.8)n.s.
IL-9 (pg mL−1)83.9 (59.0; 93.7)83.9 (75.3; 96.7)n.s.
IL-12 (pg mL−1)25.6 (16.7; 40.1)49.2 (34.9; 81.9)0.006
IL-17 (pg mL−1)125.9 (111.0; 149.4)130.5 (116.9; 164.1)n.s.
IFN-γ (pg mL−1)101.2 (91.2; 113.9)108.3 (85.4; 126.3)n.s.
TNF-α (pg mL−1)48.6 (39.7; 52.7)47.2 (39.0; 54.7)n.s.
IL-8 (pg mL−1)16.5 (12.8; 18.2)31.9 (22.0; 46.8)< 0.001
Eotaxin (pg mL−1)102.0 (63.8; 127.0)116.3 (78.6; 157.6)n.s.
IP-10 (pg mL−1)313.3 (218.4; 850.3)619.6 (528.5; 1095.1)0.021
MCP-1 (pg mL−1)7.0 (4.3; 14.5)30.3 (18.3; 39.5)0.001
MIP-1α (pg mL−1)2.7 (2.6; 3.1)3.2 (2.2; 4.5)n.s.
MIP-1β (pg mL−1)141.7 (90.5; 244.9)202.6 (162.3; 424.4)0.040
RANTES (pg mL−1)21480.8 (15677.0; 24610.0)28724.8 (26390.0; 36752.0)< 0.001