Epigenome-wide base-resolution profiling of DNA methylation in chorionic villi of fetuses with Down syndrome by methyl-capture sequencing

Table 2 Distribution of DMCs on functional genomic regions

Functional genomic regions	Hypermethlyated DMCs		Hypomethylated DMCs		Magnification of hypermethylated DMCs to hypomethylated DMCs
Functional genomic regions	n	%	n	%
Intragenic	2,539	57.2	100	2.3	25.4
5′UTR	98	2.2	2	0.0	49.0
3′UTR	146	3.3	10	0.2	14.6
Intronic	905	20.4	66	1.5	13.7
Exonic	1,390	31.3	22	0.5	63.2
Intergenic	1,216	27.4	49	1.1	24.8
Promoter	488	11.0	22	0.5	22.2
Downstream	60	1.4	0	-	-
CGI	3,053	68.8	59	1.3	51.7
CGI shore	499	11.2	23	0.5	21.7

CGI CpG island, DMCs differentially methylated CpG sites, UTR untranslated region
Percentages of DMCs on functional genomic regions was measured based on total 4439 DMCs

ISSN: 1868-7083