Table 4 Differentially methylated regions in blood
From: Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood
Gene | Position | Gene feature | n | p value | Šidák P | Average Δ% (range Δ%) |
|---|---|---|---|---|---|---|
Baseline | ||||||
LDLRAD4 | chr18:13611370-13611825 | TSS; Exon; 5′UTR; Intron | 7 (7 up; 0 down) | 3.25E−11 | 2.88E−08 | 3.64 (2.54:5.14) |
ZNF154 | chr19:58220080-58220838 | TSS; Intron; 5′UTR; CDS; Exon | 11 (11 up; 0 down) | 1.16E−09 | 6.16E−07 | 3.87 (1.75:5.11) |
PRRT1 | chr6:32116216-32117402 | Intron; 3′UTR; CDS | 26 (24 up; 2 down) | 2.61E−09 | 8.85E−07 | 1.77 (− 3.1:5.37) |
SYMPK; RSPH6A | chr19:46318514-46319399 | Intron; 3′UTR; CDS; TSS; Exon; 5′UTR | 7 (7 up; 0 down) | 6.18E−09 | 2.81E−06 | 3.2 (2.07:4.87) |
TENM3 | chr4:183728549-183729462 | Intergenic | 5 (5 up; 0 down) | 1.02E−08 | 4.48E−06 | 2.69 (− 0.67:4.25) |
GLIPR1L2; CAPS2 | chr12:75784617-75785296 | TSS; Intron; 5′UTR; CDS; Exon | 10 (10 up; 0 down) | 2.36E−07 | 1.40E−04 | 2.72 (1.85:4.5) |
GPR35 | chr2:241562085-241562758 | Intron | 6 (6 up; 0 down) | 3.16E−07 | 1.89E−04 | 3.83 (3.35:4.37) |
ZMAT2 | chr5:140079591-140080246 | TSS; Intron; 5′UTR; CDS | 10 (9 up; 1 down) | 3.86E−07 | 2.37E−04 | 1.21 (− 1.35:2.81) |
ZNF649-AS1; ZNF577 | chr19:52390810-52391368 | Exon; TSS; Intron; 5′UTR | 10 (10 up; 0 down) | 7.42E−07 | 5.35E−04 | 5.11 (2.93:6.61) |
ULK1 | chr12:132380696-132380904 | Intron | 3 (3 up; 0 down) | 3.57E−07 | 6.90E−04 | 2.1 (0.92:3.5) |
SLC44A4 | chr6:31846769-31847029 | TSS; Exon; 5′UTR | 8 (0 up; 8 down) | 4.61E−07 | 7.13E−04 | − 1.14 (− 3.86:2.41) |
OXT | chr20:3051954-3052484 | TSS; Intron; 5′UTR; CDS | 10 (9 up; 1 down) | 9.41E−07 | 7.14E−04 | 3.43 (− 0.45:6.79) |
FAM222A | chr12:110156245-110156460 | Intron; 5′UTR | 4 (4 up; 0 down) | 2.85E−06 | 5.33E−03 | 3.11 (2.66:3.43) |
CYBRD1 | chr2:172430723-172430817 | Intergenic | 3 (0 up; 3 down) | 1.83E−06 | 7.78E−03 | − 1.75 (− 2.7:− 0.26) |
RUNX2 | chr6:45391852-45391974 | Intron | 3 (3 up; 0 down) | 5.11E−06 | 1.67E−02 | 3.19 (0.74:4.53) |
Follow-up | ||||||
GSDMD | chr8:144635309-144635611 | TSS; Exon; 5′UTR | 5 (0 up; 5 down) | 7.08E−18 | 9.43E−15 | − 0.68 (− 1.53:− 0.25) |
IRGC | chr19:44203583-44203914 | Intergenic | 3 (0 up; 3 down) | 2.40E−12 | 2.92E−09 | 0.87 (− 0.32:1.53) |
LINC01149 | chr6:31409319-31409758 | Exon | 12 (0 up; 12 down) | 3.03E−10 | 2.78E−07 | − 0.96 (− 2.17:− 0.12) |
RUFY1 | chr5:178986131-178986907 | TSS; Exon; 5′UTR; Intron | 9 (9 up; 0 down) | 3.77E−09 | 1.96E−06 | 2.85 (1.3:4.19) |
GLIPR1L2; CAPS2 | chr12:75784541-75785296 | TSS; Intron; 5′UTR; CDS; Exon | 11 (11 up; 0 down) | 1.30E−08 | 6.94E−06 | 1.34 (0.64:2.81) |
RAD51B; LOC100996664 | chr14:69095057-69095680 | Intron; Exon | 5 (5 up; 0 down) | 3.57E−08 | 2.31E−05 | 6.05 (4.89:7.1) |
LOC105372397; MAP4K1 | chr19:39086733-39087768 | Intron; Exon; CDS | 5 (4 up; 1 down) | 8.14E−08 | 3.17E−05 | − 0.28 (− 1.05:0.3) |
KHDRBS2 | chr6:62996022-62996703 | Exon; TSS; 5′UTR | 11 (11 up; 0 down) | 6.92E−08 | 4.09E−05 | 1.25 (0.69:1.89) |
STAG3L5P-PVRIG2P-PILRB; STAG3L5P; PMS2P1 | chr7:99933717-99933798 | Exon | 3 (3 up; 0 down) | 1.01E−08 | 5.02E−05 | 0.16 (− 0.01:0.45) |
ISOC2 | chr19:55972646-55973339 | TSS; Intron; Exon; 5′UTR | 9 (9 up; 0 down) | 8.68E−08 | 5.04E−05 | 1.52 (0.78:2.51) |
RARRES2 | chr7:150037988-150038599 | Intron; 5′UTR | 3 (0 up; 3 down) | 1.63E−07 | 1.07E−04 | 0.71 (− 0.64:2.19) |
LINC01169 | chr15:66947171-66947618 | Intron | 5 (0 up; 5 down) | 1.54E−07 | 1.39E−04 | − 2.24 (− 5.41:− 0.83) |
TRAM1L1 | chr4:118006405-118007226 | TSS; CDS | 11 (10 up; 1 down) | 9.95E−07 | 4.88E−04 | 1.14 (− 0.81:2.96) |
LDHC | chr11:18433500-18434016 | TSS; Intron; Exon; 5′UTR | 7 (7 up; 0 down) | 6.92E−07 | 5.40E−04 | 2.76 (− 0.3:4.7) |
ZNF337-AS1; NANP | chr20:25604462-25605179 | Intron; Exon; TSS; 5′UTR; CDS | 12 (12 up; 0 down) | 1.10E−06 | 6.18E−04 | 0.4 (− 0.27:1.36) |
IFT74; IFT74-AS1 | chr9:26956236-26956770 | Intron; 5′UTR; TSS; Exon | 3 (2 up; 1 down) | 8.65E−07 | 6.52E−04 | 0.21 (− 0.2:0.52) |
MIR3659 | chr1:38599626-38600200 | Intergenic | 4 (0 up; 4 down) | 1.34E−06 | 9.38E−04 | − 0.49 (− 1.35:0.64) |
LINC01983 | chr3:195578011-195578281 | Intron | 6 (0 up; 6 down) | 6.38E−07 | 9.51E−04 | − 0.07 (− 0.76:0.67) |
HEXD | chr17:80393124-80393667 | Intron; CDS | 5 (5 up; 0 down) | 1.89E−06 | 1.40E−03 | − 0.52 (− 2.54:0.39) |
GNG7 | chr19:2543602-2544101 | Intron; 5′UTR | 5 (5 up; 0 down) | 5.29E−06 | 4.26E−03 | 1 (0.25:1.95) |
F11-AS1 | chr4:187422005-187422120 | Exon | 5 (5 up; 0 down) | 1.66E−06 | 5.81E−03 | 1.26 (0.4:1.87) |