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Table 1 Clinical profile in the tissue and plasma samples of gastric cancer patients with hypermethylation of the ADAM19, FLI1, and MSC genes

From: Analysis of the clinical significance of DNA methylation in gastric cancer based on a genome-wide high-resolution array

Variables Tissue samples Plasma samples
Case no., n = 141 ADAM19 n = 59 P value FLI1 n = 57 P value MSC n = 80 P value Case no. n = 106 ADAM19 n = 41 P value FLI1 n = 45 P value MSC n = 54 P value
Age (years)    0.597   0.860   0.860    0.537   0.860   0.686
 < 65/ 65 51/90 23/36   20/37   28/52   38/68 13/28   15/30   18/36  
Gender    0.163   0.319   0.167    1.000   0.110   0.650
 Male/female 107/34 41/18   46/11   57/23   81/25 31/10   38/7   40/14  
Tumor size (cm)    0.247   0.847   0.848    0.827   0.830   0.832
< 5/ 5 36/105 12/47   14/43   21/59   31/75 11/30   14/31   15/39  
Cell differentiation    0.814   0.666   0.221    0.843   0.434   0.119
 Poor/moderate/well 71/69/1 30/29/0   27/30/0   37/42/1   50/56/0 20/21/0   19/26/0   21/33/0  
Gross appearance    0.069   0.218   0.170    0.154   0.296   0.025
 Superficial type 18 3 (17.6)   4 (22.2)   7 (38.9)   12 0   3 (25.0)   2 (16.7)  
 Borrmann type 1 and 2 30 15 (51.7)   14 (46.7)   20 (66.7)   25 14 (56.0)   13 (52.0)   16 (64.0)  
 Borrmann type 3 and 4 93 34 (37.0)   39 (41.9)   53 (57.0)   69 27 (39.1)   29 (42.0)   36 (52.2)  
Lauren’s classification    0.718   1.000   0.591    0.667   1.000   0.591
 Intestinal/diffuse type 94/47 38/21   38/19   55/25   75/31 28/13   32/13   55/25  
Lymphovascular invasion    0.416   0.540   0.421    0.247   0.821   0.256
 Absent/present 32/109 11/48   11/46   16/64   25/81 7/34   10/35   10/44  
Pathological T category    0.440   0.003   0.758    0.053   0.009   0.243
 T1 16 4 (25.0)   4 (25.0)   8 (50.0)   12 1 (8.3)   4 (33.3)   3 (25.0)  
 T2 23 9 (39.1)   17 (73.9)   15 (65.2)   18 7 (38.9)   14 (77.8)   10 (55.6)  
 T3 34 14 (41.2)   10 (29.4)   18 (52.9)   29 12 (41.4)   9 (31.0)   14 (48.3)  
 T4 68 32 (47.1)   26 (38.2)   39 (57.4)   47 21 (44.7)   18 (38.3)   27 (57.4)  
Pathological N category    0.383   1.000   0.770    0.437   0.872   0.290
 N0 45 16 (35.6)   18 (40.0)   24 (53.3)   36 12 (33.3)   17 (47.2)   14 (38.9)  
 N1 25 12 (48.0)   10 (40.0)   15 (60.0)   21 9 (42.9)   8 (38.1)   12 (57.1)  
 N2 22 7 (31.8)   9 (40.9)   11 (50.0)   18 5 (27.8)   8 (44.4)   9 (50.0)  
 N3 49 24 (49.0)   20 (40.8)   30 (61.2)   31 15 (48.4)   12 (38.7)   19 (61.3)  
Pathological TNM stage    0.043   0.448   0.926    0.042   0.356   0.160
 I 26 8 (30.8)   11 (42.3)   15 (57.7)   21 5 (23.8)   11 (52.4)   8 (38.1)  
 II 40 16 (40.0)   19 (47.5)   22 (55.0)   32 13 (40.6)   16 (50.0)   16 (50.0)  
 III 65 27 (41.5)   23 (35.4)   38 (58.5)   48 18 (37.5)   16 (33.3)   27 (56.3)  
 IV 10 8 (80.0)   4 (40.0)   5 (50.0)   5 5 (100)   2 (40.0)   3 (60.0)