Table 1 Clinical profile in the tissue and plasma samples of gastric cancer patients with hypermethylation of the ADAM19, FLI1, and MSC genes
Variables | Tissue samples | Plasma samples | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case no., n = 141 | ADAM19 n = 59 | P value | FLI1 n = 57 | P value | MSC n = 80 | P value | Case no. n = 106 | ADAM19 n = 41 | P value | FLI1 n = 45 | P value | MSC n = 54 | P value | |
Age (years) | 0.597 | 0.860 | 0.860 | 0.537 | 0.860 | 0.686 | ||||||||
 < 65/≧ 65 | 51/90 | 23/36 | 20/37 | 28/52 | 38/68 | 13/28 | 15/30 | 18/36 | ||||||
Gender | 0.163 | 0.319 | 0.167 | 1.000 | 0.110 | 0.650 | ||||||||
 Male/female | 107/34 | 41/18 | 46/11 | 57/23 | 81/25 | 31/10 | 38/7 | 40/14 | ||||||
Tumor size (cm) | 0.247 | 0.847 | 0.848 | 0.827 | 0.830 | 0.832 | ||||||||
< 5/≧ 5 | 36/105 | 12/47 | 14/43 | 21/59 | 31/75 | 11/30 | 14/31 | 15/39 | ||||||
Cell differentiation | 0.814 | 0.666 | 0.221 | 0.843 | 0.434 | 0.119 | ||||||||
 Poor/moderate/well | 71/69/1 | 30/29/0 | 27/30/0 | 37/42/1 | 50/56/0 | 20/21/0 | 19/26/0 | 21/33/0 | ||||||
Gross appearance | 0.069 | 0.218 | 0.170 | 0.154 | 0.296 | 0.025 | ||||||||
 Superficial type | 18 | 3 (17.6) | 4 (22.2) | 7 (38.9) | 12 | 0 | 3 (25.0) | 2 (16.7) | ||||||
 Borrmann type 1 and 2 | 30 | 15 (51.7) | 14 (46.7) | 20 (66.7) | 25 | 14 (56.0) | 13 (52.0) | 16 (64.0) | ||||||
 Borrmann type 3 and 4 | 93 | 34 (37.0) | 39 (41.9) | 53 (57.0) | 69 | 27 (39.1) | 29 (42.0) | 36 (52.2) | ||||||
Lauren’s classification | 0.718 | 1.000 | 0.591 | 0.667 | 1.000 | 0.591 | ||||||||
 Intestinal/diffuse type | 94/47 | 38/21 | 38/19 | 55/25 | 75/31 | 28/13 | 32/13 | 55/25 | ||||||
Lymphovascular invasion | 0.416 | 0.540 | 0.421 | 0.247 | 0.821 | 0.256 | ||||||||
 Absent/present | 32/109 | 11/48 | 11/46 | 16/64 | 25/81 | 7/34 | 10/35 | 10/44 | ||||||
Pathological T category | 0.440 | 0.003 | 0.758 | 0.053 | 0.009 | 0.243 | ||||||||
 T1 | 16 | 4 (25.0) | 4 (25.0) | 8 (50.0) | 12 | 1 (8.3) | 4 (33.3) | 3 (25.0) | ||||||
 T2 | 23 | 9 (39.1) | 17 (73.9) | 15 (65.2) | 18 | 7 (38.9) | 14 (77.8) | 10 (55.6) | ||||||
 T3 | 34 | 14 (41.2) | 10 (29.4) | 18 (52.9) | 29 | 12 (41.4) | 9 (31.0) | 14 (48.3) | ||||||
 T4 | 68 | 32 (47.1) | 26 (38.2) | 39 (57.4) | 47 | 21 (44.7) | 18 (38.3) | 27 (57.4) | ||||||
Pathological N category | 0.383 | 1.000 | 0.770 | 0.437 | 0.872 | 0.290 | ||||||||
 N0 | 45 | 16 (35.6) | 18 (40.0) | 24 (53.3) | 36 | 12 (33.3) | 17 (47.2) | 14 (38.9) | ||||||
 N1 | 25 | 12 (48.0) | 10 (40.0) | 15 (60.0) | 21 | 9 (42.9) | 8 (38.1) | 12 (57.1) | ||||||
 N2 | 22 | 7 (31.8) | 9 (40.9) | 11 (50.0) | 18 | 5 (27.8) | 8 (44.4) | 9 (50.0) | ||||||
 N3 | 49 | 24 (49.0) | 20 (40.8) | 30 (61.2) | 31 | 15 (48.4) | 12 (38.7) | 19 (61.3) | ||||||
Pathological TNM stage | 0.043 | 0.448 | 0.926 | 0.042 | 0.356 | 0.160 | ||||||||
 I | 26 | 8 (30.8) | 11 (42.3) | 15 (57.7) | 21 | 5 (23.8) | 11 (52.4) | 8 (38.1) | ||||||
 II | 40 | 16 (40.0) | 19 (47.5) | 22 (55.0) | 32 | 13 (40.6) | 16 (50.0) | 16 (50.0) | ||||||
 III | 65 | 27 (41.5) | 23 (35.4) | 38 (58.5) | 48 | 18 (37.5) | 16 (33.3) | 27 (56.3) | ||||||
 IV | 10 | 8 (80.0) | 4 (40.0) | 5 (50.0) | 5 | 5 (100) | 2 (40.0) | 3 (60.0) | ||||||