Table 4 Non-parametric estimates of sensitivity, specificity, positive and negative likelihood ratios of prostate cancer detection in the third sampling, for increasing thresholds (from > 5 to > 10%) of GSTP1 methylation observed in the first and second negative biopsy; 97 cases and 109 controls with measured GSTP1 methylation in both the first and the second biopsy
From: DNA methylation in repeat negative prostate biopsies as a marker of missed prostate cancer
Methylation threshold | n positive cases | n negative cases | n positive controls | n negative controls | Sens | Spec | LR+ | LR− |
|---|---|---|---|---|---|---|---|---|
The highest methylation level between the first and second biopsy | ||||||||
> 5% | 44 | 53 | 22 | 87 | 0.45 | 0.80 | 2.25 | 0.68 |
> 6% | 32 | 65 | 12 | 97 | 0.33 | 0.89 | 3.00 | 0.75 |
> 7% | 27 | 70 | 8 | 101 | 0.28 | 0.93 | 3.79 | 0.78 |
> 8% | 19 | 78 | 4 | 105 | 0.20 | 0.96 | 5.34 | 0.83 |
> 9% | 17 | 80 | 3 | 106 | 0.17 | 0.97 | 6.37 | 0.85 |
> 10% | 14 | 83 | 2 | 107 | 0.14 | 0.98 | 7.87 | 0.87 |