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Table 4 Non-parametric estimates of sensitivity, specificity, positive and negative likelihood ratios of prostate cancer detection in the third sampling, for increasing thresholds (from > 5 to > 10%) of GSTP1 methylation observed in the first and second negative biopsy; 97 cases and 109 controls with measured GSTP1 methylation in both the first and the second biopsy

From: DNA methylation in repeat negative prostate biopsies as a marker of missed prostate cancer

Methylation threshold n positive cases n negative cases n positive controls n negative controls Sens Spec LR+ LR−
The highest methylation level between the first and second biopsy
> 5% 44 53 22 87 0.45 0.80 2.25 0.68
> 6% 32 65 12 97 0.33 0.89 3.00 0.75
> 7% 27 70 8 101 0.28 0.93 3.79 0.78
> 8% 19 78 4 105 0.20 0.96 5.34 0.83
> 9% 17 80 3 106 0.17 0.97 6.37 0.85
> 10% 14 83 2 107 0.14 0.98 7.87 0.87
  1. Sens sensitivity, Spec specificity, LR likelihood ratio