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Table 2 Platelet and WBC variable distribution in the Moli-family cohort

From: Variation of PEAR1 DNA methylation influences platelet and leukocyte function

Variable

Moli-family (n = 605)

Platelet measurements

 Platelet count, 109/L

249.4 ± 60,6

 Mean platelet volume, fL

8.59 ± 0.98

 Plateletcrit, %

0.21 ± 0.05

 Platelet distribution width, %

16.4 ± 0.6

 Soluble P-selectin, μg/L

82.7 ± 38.0

 Platelet P-selectin, %

2.76 ± 3.65

 Platelet/monocytes aggregates, %

7.24 ± 8.62

 Platelet/PMN aggregates, %

4.32 ± 5.02

Inflammation measurements

 White blood cell count, 109/L

6.19 ± 1.52

 Neutrophils, %

61.0 ± 8.0

 Lymphocyte, %

32.0 ± 7.0

 Neutrophil/lymphocyte ratio

2.08 ± 0.83

 Monocyte, %

7.0 ± 2.0

 Red blood cell, 1012/L

4.89 ± 0.5

 Platelet/lymphocyte ratio

135.9 ± 47.6

 INFLAscore*

− 0.23 ± 5.59

 C-reactive protein, mg/mL

1.7 ± 1.74

 Monocyte L-selectin, %

10.4 ± 7.2

 PMN L-selectin, %

25.7 ± 21.3

 Monocyte CD11b, %

51.5 ± 24.1

 PMN CD11b, %

44.0 ± 25.1

  1. *INFLAscore is calculated as follows: 10 tiles of each biomarker levels (CRP, WBC, platelets, G/L ratio) were generated. For all four components, being in the highest deciles (7 to 10) gave a score which increased from 1 to 4, while being in the lowest deciles (1 to 4) was negatively scored from − 4 to − 1. Being in the deciles 5 or 6 got zero points. In such a way, the INFLA-score ranges from − 16 to 16 and comes up as the sum of the four biomarkers. An increase in the score represented an increase in low-grade inflammation intensity