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Table 2 Platelet and WBC variable distribution in the Moli-family cohort

From: Variation of PEAR1 DNA methylation influences platelet and leukocyte function

Variable Moli-family (n = 605)
Platelet measurements
 Platelet count, 109/L 249.4 ± 60,6
 Mean platelet volume, fL 8.59 ± 0.98
 Plateletcrit, % 0.21 ± 0.05
 Platelet distribution width, % 16.4 ± 0.6
 Soluble P-selectin, μg/L 82.7 ± 38.0
 Platelet P-selectin, % 2.76 ± 3.65
 Platelet/monocytes aggregates, % 7.24 ± 8.62
 Platelet/PMN aggregates, % 4.32 ± 5.02
Inflammation measurements
 White blood cell count, 109/L 6.19 ± 1.52
 Neutrophils, % 61.0 ± 8.0
 Lymphocyte, % 32.0 ± 7.0
 Neutrophil/lymphocyte ratio 2.08 ± 0.83
 Monocyte, % 7.0 ± 2.0
 Red blood cell, 1012/L 4.89 ± 0.5
 Platelet/lymphocyte ratio 135.9 ± 47.6
 INFLAscore* − 0.23 ± 5.59
 C-reactive protein, mg/mL 1.7 ± 1.74
 Monocyte L-selectin, % 10.4 ± 7.2
 PMN L-selectin, % 25.7 ± 21.3
 Monocyte CD11b, % 51.5 ± 24.1
 PMN CD11b, % 44.0 ± 25.1
  1. *INFLAscore is calculated as follows: 10 tiles of each biomarker levels (CRP, WBC, platelets, G/L ratio) were generated. For all four components, being in the highest deciles (7 to 10) gave a score which increased from 1 to 4, while being in the lowest deciles (1 to 4) was negatively scored from − 4 to − 1. Being in the deciles 5 or 6 got zero points. In such a way, the INFLA-score ranges from − 16 to 16 and comes up as the sum of the four biomarkers. An increase in the score represented an increase in low-grade inflammation intensity