Variation of PEAR1 DNA methylation influences platelet and leukocyte function

Clinical Epigenetics

Table 1 General characteristics of Moli-family participants

Characteristic	Moli-family
Number (%) of participants	605
Women	330 (54.5)
Current smoking	165 (27.4)
Drinking alcohol^a	122 (21.8)
Hypertension	206 (34.2)
Diabetes	36 (6.0)
Mean (± SD) characteristic
Age, years	42.3 ± 18.8
Body mass index, kg/m²	26.5 ± 5.4
Blood pressure, mm Hg
Systolic	130.2 ± 20.6
Diastolic	77.1 ± 11.6
Total serum cholesterol, mmol/L	5.06 ± 1.10
HDL cholesterol, mmol/L	1.49 ± 0.38
Total-to-HDL cholesterol ratio	3.56 ± 1.03

HDL indicates high-density lipoprotein. Hypertension was a blood pressure of ≥ 140 mmHg systolic or ≥ 90 mmHg diastolic or use of antihypertensive drugs. Diabetes mellitus was a fasting plasma glucose level of ≥ 7.0 mmol/L or use of antidiabetic agents
^aDefined as drinking at least 15 g of alcohol daily

ISSN: 1868-7083