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Table 7 Variation of the methylation patterns of CpG sites located in NUDT15 and TNXRD1 from validation

From: Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

Gene

Gene feature

CpG

Sites

Fold change in methylation (MCI vs. control)

FDR adjusted P value

NUDT15

TSS1500

cg01596986

CpG_1

0.751

0.586

CpG_2

0.955

0.714

CpG_3

0.955

0.714

CpG_4

0.795

0.089

CpG_5

1.180

0.122

CpG_6

0.649

0.842

CpG_7

1.078

0.973

CpG_8

0.992

0.975

CpG_9

1.105

0.910

CpG_10

2.351

0.582

CpG_11

1.048

0.476

CpG_12

1.062

0.661

CpG_13

0.919

0.582

CpG_14

1.026

0.810

CpG_15

0.959

0.935

CpG_16

1.088

0.447

CpG_17

1.157

0.030*

CpG_18

1.210

0.525

CpG_19

1.288

0.024*

CpG_20

0.952

0.529

CpG_21

1.210

0.525

CpG_22

1.245

0.276

CpG_23

1.022

0.935

CpG_24

1.092

0.594

CpG_25

1.119

0.529

TXNRD1

5′UTR

cg12166806

CpG_1

0.917

0.714

CpG_2

0.787

0.615

CpG_3

1.495

0.375

CpG_4

1.092

0.375

CpG_5

0.941

0.890

CpG_6

1.092

0.375

CpG_7

1.156

0.447

CpG_8

1.217

0.386

CpG_9

1.015

0.029*

CpG_10

0.987

0.910

CpG_11

1.191

0.018*

CpG_12

1.120

0.910

CpG_13

0.982

0.975

CpG_14

0.940

0.475

CpG_15

1.139

0.241

CpG_16

1.054

0.626

CpG_17

1.310

0.475

  1. FDR false discovery rate, NUDT15 nudix hydrolase 15, TXNRD1 thioredoxin reductase 1, TSS1500 1500 base pairs around the transcription start site, 5′UTR 5’untranslated region
  2. ∗P<0.05
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Clinical Epigenetics

ISSN: 1868-7083

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