Skip to main content

Advertisement

Table 7 Variation of the methylation patterns of CpG sites located in NUDT15 and TNXRD1 from validation

From: Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

Gene Gene feature CpG Sites Fold change in methylation (MCI vs. control) FDR adjusted P value
NUDT15 TSS1500 cg01596986 CpG_1 0.751 0.586
CpG_2 0.955 0.714
CpG_3 0.955 0.714
CpG_4 0.795 0.089
CpG_5 1.180 0.122
CpG_6 0.649 0.842
CpG_7 1.078 0.973
CpG_8 0.992 0.975
CpG_9 1.105 0.910
CpG_10 2.351 0.582
CpG_11 1.048 0.476
CpG_12 1.062 0.661
CpG_13 0.919 0.582
CpG_14 1.026 0.810
CpG_15 0.959 0.935
CpG_16 1.088 0.447
CpG_17 1.157 0.030*
CpG_18 1.210 0.525
CpG_19 1.288 0.024*
CpG_20 0.952 0.529
CpG_21 1.210 0.525
CpG_22 1.245 0.276
CpG_23 1.022 0.935
CpG_24 1.092 0.594
CpG_25 1.119 0.529
TXNRD1 5′UTR cg12166806 CpG_1 0.917 0.714
CpG_2 0.787 0.615
CpG_3 1.495 0.375
CpG_4 1.092 0.375
CpG_5 0.941 0.890
CpG_6 1.092 0.375
CpG_7 1.156 0.447
CpG_8 1.217 0.386
CpG_9 1.015 0.029*
CpG_10 0.987 0.910
CpG_11 1.191 0.018*
CpG_12 1.120 0.910
CpG_13 0.982 0.975
CpG_14 0.940 0.475
CpG_15 1.139 0.241
CpG_16 1.054 0.626
CpG_17 1.310 0.475
  1. FDR false discovery rate, NUDT15 nudix hydrolase 15, TXNRD1 thioredoxin reductase 1, TSS1500 1500 base pairs around the transcription start site, 5′UTR 5’untranslated region
  2. P<0.05