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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

Fig. 5

H1-3 protein expression is lower in H3K27me3 HIST1high patients. a Abundance of histone H1 subtypes. Results of each H1 subtype are expressed in iBAQ (Log2) adjusted on the median of the total protein extracted and normalized to total histone amount by patients. Statistical significance was estimated using unpaired t test, (*) p < 0.05. NS non significant. b Immunoblots of H3, H1, and H1-3 on patient chromatin bound extracts. The arrow points to the specific band for H1-3. Ratio of H1-3/total-H1 is calculated using Mean Signal Intensity on imageJ software

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