Table 3 Differential variation of clinical variables along time between the constant methylation and the methylation increase groups

CpG methylation Index

64.9 (52.0–76.3)

0.244

0 (0–0)

0.001

74.8 (74.7–86.9)

0.902

12.9 (0–77.0)

0.071

77.9 (70.8–86.7)

Additional CpG methylation Index ^c

21.7 (9.4–34.9)

0.282

0 (0–1.7)

0.003

27 (8.6–40.6)

0.282

27.0 (0–50.0)

0.219

20.0 (13.8–20.0)

Non–CpG methylation Index^d

2.6 (0–8.3)

0.352

0 (0–11.2)

0.585

0 (0–3)

0.560

0 (0–0)

0.356

0 (0–2.2)

Residual pVL (RNA copies/ml)

1.4 (0–1.5)

0.699

1.0 (0–3.6)

0.862

0 (0–4.2)

0.842

3.5 (0.6–7.1)

0.164

0.4 (0–2.9)

Proviral load (DNA copies/million CD4⁺ T cells)

15241 (3800–25166)

0.462

11250 (22–29277)

0.745

3638 (2155–9012)

0.221

4264 (10–17670)

0.515

9780 (4057–13716)

Naive CD4⁺ T cells (%)

25.2 (23.9–45.7)

0.713

28.0 (4.2–64.1)

0.828

29.1 (27.7–49.1)

0.713

26.3 (4.8–47.0)

0.588

39.4 (11.2–45.4)

Memory CD4⁺ T cells (%)

74.8 (54.3-76.2)

0.713

72.1 (35.9–95.8)

0.828

70.9 (50.9–72.3)

0.713

73.7 (53.0–95.2)

0.588

60.6 (54.6–88.8)

 T_SCM (%)

6.4 (4.7–6.6)

0.221

4.5 (1.0–6.9)

0.051

4.2 (2.9–7.4)

0.111

4.7 (3.4–6.2)

0.065

9.4 (5.7–15.9)

 T_CM (%)

23.2 (23.2–28.8)

0.713

22.3 (15.3–35.1)

0.745

21.7 (12.7–33.0)

0.540

21.9 (15.5–32.5)

0.515

23.8 (19.5–40.9)

 T_EM (%)

12.5 (5.4–17.2)

0.270

9.2 (2.1–26.5)

0.745

9.0 (7.6–10.1)

0.462

12.1 (3.2–13.8)

0.193

6.3 (4.8–9.3)

 T_TM (%)

13.3 (12.6–15.1)

0.221

15.2 (11.3–25.4)

0.129

11.6 (11.4–19.5)

0.142

17.4 (11.7–31.5)

0.083

8.3 (4.5–16.6)

 T_NEW (%)

1.4 (0.6–1.56)

0.075

1.1 (0.6–1.2)

0.002

2.5 (1.6–4.1)

0.624

2.7 (2.3–3.3)

0.588

2.0 (1.5–3.9)

 T_TE (%)

4.0 (0.3–11.8)

0.713

1.5 (0.3–4.5)

0.083

3.9 (1.2–9.6)

0.806

6.3 (2.2–9.8)

0.914

4.8 (2.7–7.8)