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Table 3 Differential variation of clinical variables along time between the constant methylation and the methylation increase groups

From: Longitudinal variation in human immunodeficiency virus long terminal repeat methylation in individuals on suppressive antiretroviral therapy

  Short-term ART group (30 months) Short-term ART group (42 months) Long-term ART group
Constant methylation group p valuea Methylation increase group p valueb Constant methylation group p valuea Methylation increase group p valueb
CpG methylation Index 64.9 (52.0–76.3) 0.244 0 (0–0) 0.001 74.8 (74.7–86.9) 0.902 12.9 (0–77.0) 0.071 77.9 (70.8–86.7)
Additional CpG methylation Index c 21.7 (9.4–34.9) 0.282 0 (0–1.7) 0.003 27 (8.6–40.6) 0.282 27.0 (0–50.0) 0.219 20.0 (13.8–20.0)
Non–CpG methylation Indexd 2.6 (0–8.3) 0.352 0 (0–11.2) 0.585 0 (0–3) 0.560 0 (0–0) 0.356 0 (0–2.2)
Residual pVL (RNA copies/ml) 1.4 (0–1.5) 0.699 1.0 (0–3.6) 0.862 0 (0–4.2) 0.842 3.5 (0.6–7.1) 0.164 0.4 (0–2.9)
Proviral load (DNA copies/million CD4+ T cells) 15241 (3800–25166) 0.462 11250 (22–29277) 0.745 3638 (2155–9012) 0.221 4264 (10–17670) 0.515 9780 (4057–13716)
Naive CD4+ T cells (%) 25.2 (23.9–45.7) 0.713 28.0 (4.2–64.1) 0.828 29.1 (27.7–49.1) 0.713 26.3 (4.8–47.0) 0.588 39.4 (11.2–45.4)
Memory CD4+ T cells (%) 74.8 (54.3-76.2) 0.713 72.1 (35.9–95.8) 0.828 70.9 (50.9–72.3) 0.713 73.7 (53.0–95.2) 0.588 60.6 (54.6–88.8)
 TSCM (%) 6.4 (4.7–6.6) 0.221 4.5 (1.0–6.9) 0.051 4.2 (2.9–7.4) 0.111 4.7 (3.4–6.2) 0.065 9.4 (5.7–15.9)
 TCM (%) 23.2 (23.2–28.8) 0.713 22.3 (15.3–35.1) 0.745 21.7 (12.7–33.0) 0.540 21.9 (15.5–32.5) 0.515 23.8 (19.5–40.9)
 TEM (%) 12.5 (5.4–17.2) 0.270 9.2 (2.1–26.5) 0.745 9.0 (7.6–10.1) 0.462 12.1 (3.2–13.8) 0.193 6.3 (4.8–9.3)
 TTM (%) 13.3 (12.6–15.1) 0.221 15.2 (11.3–25.4) 0.129 11.6 (11.4–19.5) 0.142 17.4 (11.7–31.5) 0.083 8.3 (4.5–16.6)
 TNEW (%) 1.4 (0.6–1.56) 0.075 1.1 (0.6–1.2) 0.002 2.5 (1.6–4.1) 0.624 2.7 (2.3–3.3) 0.588 2.0 (1.5–3.9)
 TTE (%) 4.0 (0.3–11.8) 0.713 1.5 (0.3–4.5) 0.083 3.9 (1.2–9.6) 0.806 6.3 (2.2–9.8) 0.914 4.8 (2.7–7.8)
  1. In all cases, medians (interquartile ranges) are shown. Significant p values (p < 0.05) are shown in italic
  2. ART antiretroviral therapy, pVL plasma viral load, TSCM stem cell memory T cells, TCM central memory T cells, TEM effector memory T cells, TTM transitional memory T cells, TNEW T new, TTE terminally differentiated effector T cells
  3. aConstant methylation group vs. long-term ART group
  4. bMethylation increase group vs. long-term ART group
  5. cConsiders methylation of CpG positions not present in the reference HXB2
  6. dConsiders methylation of non-CpG positions only.