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Table 1 Baseline characteristics of the short-term constant methylation and methylation increase groups compared to the long-term ART group

From: Longitudinal variation in human immunodeficiency virus long terminal repeat methylation in individuals on suppressive antiretroviral therapy

  Short-Term ART group
Combined
n = 12
p valuea Short-Term ART group
Constant methylation
n = 5
p valueb Short-Term ART group
Methylation increase
n = 7
p valuec p valued Long-term ART group
n = 10
Sex (Male/Female) 11:1   5:0   6:1    9:1
Age (years) 39 (33–47) 0.013 41 (38–45) 0.910 34 (31–48) 0.004 < 0.001 45 (39–56)
Nadir CD4+ T cell count (cells/mm3) 71 (7–251) 0.294 128 (12–264) 0.843 13 (4–212) 0.106 0.075 96 (47–234)
Pre-ART pVL (RNA copies/mL) 194,077 (67,293–285,046) 0.077 144,952 (90,736–243,202) 0.174 248219 (59,479–285,552) 0.048 0.205 47,800
(7581–154,809)
Delta CD4+ T cell count at 48 months (cells/mm3) 388 (174–502) < 0.001 330 (130–412) 0.843 455 (214–580) 0.029 < 0.001 291 (193–341)
Delta CD4 % at 48 months 13 (11–20) 0.163 12 (10–15) 0.190 13 (12–32) 0.023 0.041 11 (6–14.5)
Delta CD8+ T cell count at 48 months (cells/mm3) 172 (− 104, 315) 0.053 102 (− 109, 246) 0.751 202 (− 89, 325) 0.105 0.023 − 85 (− 405, 331)
Delta CD8 % at 48 months − 15 (− 24, − 5) 0.268 − 13 (− 17, 3) 0.015 − 24 (− 25, − 10) 0.162 < 0.001 − 32 (− 46, − 9)
Delta CD4/CD8 at 48 months 0.40 (0.24–0.80) 0.058 0.33 (0.23–0.35) 0.668 0.53 (0.28–0.84) 0.036 < 0.001 0.35 (0.25–0.55)
Days to undetectable pVL 183 (101–368) 0.287 186 (99–384) 0.551 180 (107–344) 0.771 0.205 148 (95–379)
Third drug in current ART regimen (NNRTIs / PIs) 83% / 17% 0.624 80% / 20% 1 86% / 14% 0.603 1 70% / 30%
Number of ART regimen changes 0 (0–1) 0.027 0 (0–0) 0.003 1 (0–1) 0.102 0.008 1 (0.8–2)
  1. For each variable, median (interquartile range) is shown
  2. ART antiretroviral therapy, pVL plasma viral load, NNRTI non-nucleoside reverse transcriptase inhibitors, PI protease inhibitors. Significant p values (p < 0.05) are shown in italic
  3. aShort-term ART group vs. long-term ART group
  4. bConstant methylation group vs. long-term ART group
  5. cMethylation increase group vs. long-term ART group
  6. dConstant methylation group vs. methylation increase group