Fig. 3

Detailed time trends of HIV 5′-LTR methylation in two model participants. Detailed variant composition per time point (30, 33, 36, 39, 42, 45, 48, 51, and 54 months) is shown for participants a TP25, representative of the methylation increase group, and b TP31, representative of the constant methylation group. Each horizontal line represents a variant. The number of reads representing that variant and its proportion in the sample are shown on the right. Each circle represents a canonical CpG site, numbered according to the HXB2 reference: black—methylated, white—non-methylated, gray—mutated