Fig. 2
From: Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease
Differentially methylated sites associated with Alzheimer’s disease in the anterior hippocampus. DNA methylation profiles of anterior hippocampus samples of 10 non-twin subjects, including six references and four with Alzheimer’s disease (AD), were examined with reduced representation bisulfite sequencing. The samples were from NIH NeuroBioBank. a Differentially methylated sites (201 CpGs) were identified with MethylKit package in R by using a minimum of 15% methylation difference and q value below 0.05 as filtering cutoff (Additional file 2d). The 201 differentially methylated CpG sites overlapped or were closest to 176 genes (AD-associated genes in the brain). Examples of the genes are shown. b Overlap of genes with AD-associated DNA methylation marks in both peripheral blood and anterior hippocampus of the brain