Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children

Table 8 Mediation analysis between cg23381058, total breastfeeding duration, and BMI trajectory 3 (early transient overweight)

	Total breastfeeding duration				Exclusive breastfeeding duration
	Beta	95% CI Lower	95% CI Upper	P value	Beta	95% CI Lower	95% CI Upper	P value
ACME	5.81E−05	− 2.46E−04	4.31E−04	0.73	2.48E−04	− 3.1E−04	1.19E−03	0.42
ADE	− 2.43E−03	− 4.94E−03	1.16E−04	0.06	− 2.25E−03	− 7.27E−03	2.76E−03	0.36
Total effect	− 2.37E−03	− 4.91E−03	1.42E−04	0.07	− 2.00E-03	− 7.07E−03	3.06E−03	0.42
Prop. mediated	− 2.45E−02	− 4.19E−01	2.72E−01	0.76	− 0.12	− 1.66	1.54	0.72

Columns: Effects— ACME average causal mediation effects, ADE average direct effects, Total effect, sum of a mediation (indirect) effect and a direct effect, Prop. mediated proportion of the total effect explained by the mediator

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