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Table 8 Mediation analysis between cg23381058, total breastfeeding duration, and BMI trajectory 3 (early transient overweight)

From: Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children

  Total breastfeeding duration Exclusive breastfeeding duration
  Beta 95% CI Lower 95% CI Upper P value Beta 95% CI Lower 95% CI Upper P value
ACME 5.81E−05 − 2.46E−04 4.31E−04 0.73 2.48E−04 − 3.1E−04 1.19E−03 0.42
ADE − 2.43E−03 − 4.94E−03 1.16E−04 0.06 − 2.25E−03 − 7.27E−03 2.76E−03 0.36
Total effect − 2.37E−03 − 4.91E−03 1.42E−04 0.07 − 2.00E-03 − 7.07E−03 3.06E−03 0.42
Prop. mediated − 2.45E−02 − 4.19E−01 2.72E−01 0.76 − 0.12 − 1.66 1.54 0.72
  1. Columns: Effects— ACME average causal mediation effects, ADE average direct effects, Total effect, sum of a mediation (indirect) effect and a direct effect, Prop. mediated proportion of the total effect explained by the mediator