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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children

Fig. 1

A mediation model for the association between breastfeeding duration (total and exclusive) and childhood obesity. βM represents the effect estimate for breastfeeding duration on DNA methylation (CpG ~ breastfeeding duration + covariates); βY represents the effect estimate for CpG on childhood obesity (BMI trajectory ~ CpG + covariates; βc represents the direct effect (no mediation) estimate for breastfeeding duration on childhood obesity (BMI trajectory ~ breastfeeding duration + covariates; βc′ represents the total effect estimate on childhood obesity (BMI trajectory = breastfeeding duration + covariates + CpG)

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