Fig. 8

Comparison of BPA-, BPF-, and BPS-induced DMPs in MCF-7 cells with DMPs in breast cancer patients. DMPs and genes encompassing DMPs in MCF-7 cells treated for 48 h with functional doses of BPA, BPF, and BPS were compared with those of 595 ER-positive tumor tissues relative to 124 normal-adjacent tissues of The Cancer Genome Atlas (TCGA) breast cancer patients. Venn diagrams of DMPs and genes encompassing DMPs of BPA, BPF, BPS, and breast cancer are shown in A1–A3 and B1–B3, respectively. Pathways of the genes encompassing DMPs of BPA, BPF, BPS, and breast cancer were detected based on KEGG pathway database using Enrichr (http://amp.pharm.mssm.edu/Enrichr/) and shown in C1 and C2. BPF was not included in C2, because its DMP-derived genes were not significantly involved in any pathway (as shown in C1)