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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair

Fig. 5

Co-administration of chidamide and MI-3 suppresses tumor growth in a xenograft model of MLL-r AML. a A scheme for the animal study that are described in detail in the “Materials and methods” section. b Mice were weighed daily after tumor cell inoculation. c–e Mice were sacrificed after drug treatment for 14 days, and then the images of mice and tumors were captured (c). Weight (d) and volume (e) of tumors were measured and calculated. Values indicate mean ± SEM for 6 mice/each group (**P < 0.01, ***P < 0.001). f Tumors sections were prepared and stained by H&E for histological examination

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