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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Promoter methylation of SEPT9 as a potential biomarker for early detection of cervical cancer and its overexpression predicts radioresistance

Fig. 2

SEPT9 is overexpressed in cervical squamous cell carcinoma (CSCC). a SEPT9 mRNA expression in cervical cancer samples and adjacent normal cervical samples. b Methylation of SEPT9 in cervical cancer tissues and para-carcinoma tissues. c The positive correlation between SEPT9 DNA methylation and mRNA expression. d The protein expression levels of SEPT9 in the cervical cancer tissues and normal para-carcinoma tissues were measured by Western blot. e The distribution of immunohistochemical score, showed in histogram, indicates that SEPT9 has a significantly higher expression in CSCC. f Representative images of immunohistochemical staining of SEPT9 in the cancer tissues and normal cervical tissues (× 100 magnification). g The high expression of SEPT9 accounted for a higher proportion in the patients with positive lymph nodes. h A Kaplan-Meier depiction of progression-free survival by the expression of SEPT9. *P < 0.05, ***P < 0.001

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