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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome

Fig. 3

TET1 oxidation of 5mC through to unmodified cytosine. After the deposition of 5-methylcytosine by the DNMT enzymes it can be oxidised by the TETs to 5-hydroxymethylcytosine, 5-formylcytosine, and then 5-carboxylcytosine, before base excision repair resulting in unmodified cytosine. These iterative oxidation steps can be inhibited by the TCA cycle metabolites succinate and fumarate

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Clinical Epigenetics

ISSN: 1868-7083

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