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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson’s disease patients

Fig. 1

DMCpGs detected by whole-genome bisulfite sequencing in iPSC-derived DAn from L2PD, sPD, and control subjects. a Total of hypo-methylated (light blue) and hyper-methylated (dark blue) DMCpGs and total DMCpGs (grey). Unique PD (Uniq PD) comprises PD-specific DMCpGs detected in L2PD vs. control and in sPD vs. controls but not in L2PD vs. sPD. b Histogram of absolute frequencies of overall CpG methylation levels in study subjects. c Circus plot of whole-genome DNA methylation changes in study subjects. The outer circle displays an ideogram ordered by chromosome number

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