Skip to main content

Table 7 ASSURE patient plasma: IPA® analysis of the proteins in ASSURE patient plasma significantly affected by apabetalone versus placebo

From: Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Ingenuity® Pathway Analysis

Pathway/regulator

z-score

p value of overlap

Target molecules in dataset

Canonical pathway

HMGB1 signaling

− 1.7

2.8 × 10−7

TLR4, VCAM1, ICAM1, IL5, PTPN11, GRB2, OSM, IL17F, IL17B, TNFRSF11B

Upstream regulators

MIF

− 2.1

8.9 × 10−10

CD84, CRP, CXCL2, CXCL3, ICAM1, IL17RA, IL5, LTBR, MET, MMP3, TLR4, VCAM1

Upstream regulators

TNFα

− 2.1

1.8 × 10−23

ANGPT2, APCS, APP, ASGR1, BGN, BID, C5, CASP3, CCDC80, CCL1, CCL5, CD38, CHI3L1, CRP, CX3CL1, CXCL13, CXCL2, CXCL3, DLL4, ENTPD5, EPHB2, FCER2, FCGR2B, FLT4, FN1, FRZB, GFRA2, GSTP1, HSP90AB1, HSPA8, HSPD1, ICAM1, IGF1R, IL18BP, IL18R1, IL5, INSR, KIT, LTBR, LY96, LYN, MET, MMP12, MMP3, MST1, NME1, OSM, PAPPA, PDGFB, PI3, PLA2G2A, POSTN, PPIF, PRKCD, PTHLH, PTPN11, SERPIND1, SPARC, TEK, TF, TIE1, TLR4, TNFRSF11B, VCAM1

Upstream regulators

CD40LG

− 2.3

1.8 × 10−4

ANXA6, CCL5, CD38, CXCL2, FCER2, FCGR2B, ICAM1, JAK2, TNFRSF11B, TNFRSF17, VCAM1, ZAP70

Upstream regulators

IFNγ (complex)

− 2.4

1.8 × 10−8

CASP3, CCL5, CHI3L1, FN1, ICAM1, IL17RA, IL18BP, JAK2, LY96, TLR4

Upstream regulators

IL-6

− 2.5

1.1 × 10−20

ADGRE5, APCS, APP, BGN, CASP3, CCL3L1, CCL5, CD38, CRP, CXCL13, CXCL2, CXCL3, ENO2, FCER2, FN1, GRK2, HFE2, HPX, ICAM1, IL17F, IL5, IL6R, JAK2, KIT, LAG3, LY96, MET, MMP12, MMP3, PDGFB, PLA2G2A, PPBP, REG1A, ROR1, SST, TF, TLR4, TNFRSF11B, TNFRSF17, VCAM1

Upstream regulators

CSF2

− 2.6

1.6 × 10−7

ADGRE5, BID, BSG, CD33, CD38, CXCL2, FCGR2B, HSPD1, ICAM1, IL5, JAK2, LY96, MET, OSM, PPIF, RAD51, SLAMF7, TLR4

Upstream regulators

IL-1β

− 2.8

4.8 × 10−19

APCS, APP, ASAH2, BGN, C1R, CASP3, CCL1, CCL3L1, CCL5, CHI3L1, CRP, CX3CL1, CXCL13, CXCL2, CXCL3, DLL4, FCER2, FCGR2B, FN1, IBSP, ICAM1, IL17F, IL18R1, IL6R, INSR, LY96, MMP12, MMP3, OSM, PAPPA, PDGFB, PGAM1, PI3, PLA2G2A, POSTN, PRKCD, PTHLH, REN, SPARC, TLR4, TNFRSF11B, VCAM1

  1. Negative activation z-scores reflect the predicted suppression of a pathway or an upstream regulator (significant when < ~− 2)
  2. P value reflects the overlap between the genes in the data set that are significantly affected by treatment (> 10% change, p < 0.05) and the genes that are in the pathway (canonical) or regulated by the upstream regulator
  3. Gene symbols are provided for the protein contributors that populate the identified pathways or upstream regulators
  4. Italicized pathways and regulators are also found in the HUVEC NanoString IPA analysis (Table 4)
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us