Table 6 THP-1 cytokine, chemokine, TLR signaling, and adhesion transcripts impacted by TNFα and apabetalone treatment
Function | Genes | TNFα | ||
|---|---|---|---|---|
Fold induction | % reduction | |||
Control | Apabetalone 5 μM | Apabetalone 20 μM | ||
Cytokines | IL-1β | 3.5 | − 75 | − 84 |
TNFα | 3.8 | NS | − 54 | |
Chemokines | CCR1 | 1.4 | − 51 | − 85 |
CCR2 | 0.5 | − 50 | − 92 | |
MCP-1 | 3.7 | − 77 | − 91 | |
TLR signaling | MYD88 | 2.6 | − 39 | − 71 |
TLR4 | 0.7 | NS | − 51 | |
Adhesion molecules | CD44 | 1.8 | − 26 | − 39 |
VLA-4 | 0.9 | − 35 | − 61 | |