Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein

Clinical Epigenetics

Table 5 The methylation status of CpG locus (the total and each tested) at PKCΒ gene promoter. The data was expressed as mean ± SEM. PE pre-eclampsia, NP normal pregnant. P < 0.05; P < 0.01; P < 0.001

Gene	Position	NP	PE
PKCB	31	0.009 ± 0.0003	0.007 ± 0.0008
	32	0.009 ± 0.0013	0.011 ± 0.0013
	33	0.010 ± 0.0008	0.009 ± 0.0007
	34	0.014 ± 0.0003	0.013 ± 0.0007
	35	0.008 ± 0.0006	0.011 ± 0.0018
	36	0.007 ± 0.0008	0.008 ± 0.0009
	37	0.008 ± 0.0006	0.009 ± 0.0007
	38	0.016 ± 0.0048	0.084 ± 0.0156*
	39	0.021 ± 0.0095	0.108 ± 0.0166***
	40	0.121 ± 0.0696	0.186 ± 0.0536*
	41	0.063 ± 0.0234	0.134 ± 0.0237**
	42	0.014 ± 0.0018	0.014 ± 0.0016
	43	0.028 ± 0.0117	0.043 ± 0.0178
	44	0.008 ± 0.0011	0.008 ± 0.0010
	Average	0.024 ± 0.0038	0.046 ± 0.0096**

ISSN: 1868-7083