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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

Fig. 5

Overexpressed HDAC4, HDAC6, or MEK can partially reverse the apoptotic effect of combination. AsPC-1 cells were transfected with empty vector, HDAC1, HDAC4, HDAC6, or GFP-MEK overnight and then co-treated with 2 μM MPT0E028 and 20 μM PD98059 for 48 h. a The protein expression of HDAC1, HDAC4, HDAC6, b caspase-3, and PARP. Actin was used as an internal control. c MEK, GFP, and PARP expressions were determined after overexpressed MEK AsPC1 cells co-treated with MPTE028 (2 μM) and PD98059 (20 μM). C control, E MPT0E028, PD PD98059

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Clinical Epigenetics

ISSN: 1868-7083

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