Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis

Clinical Epigenetics

Table 2 BS-DMPs (adjusted P value < 0.05) associated with multiple sclerosis (cohort 1)

probeID	Chr	Pos	mean_MS	mean_ctr	Δβ	P value	adj. P value	Gene name^a	Feature^a
cg25139877	1	247691111	0.90	0.88	0.02	1.02E−06	0.0391	LOC148824	Body
cg19274180	2	2726437	0.62	0.39	0.23	6.79E−08	0.0062	–	–
cg03466083	5	139088813	0.51	0.42	0.08	5.85E−07	0.0273	–	–
cg00211215	6	32552246	0.32	0.23	0.09	1.14E−08	0.0028	HLA-DRB1	Body
cg01414268	8	2480911	0.26	0.20	0.06	1.10E−06	0.0391	–	–
cg10596483	8	143751796	0.35	0.47	− 0.12	7.26E−08	0.0062	JRK	TSS1500
cg27224751	15	41096921	0.53	0.79	− 0.26	8.73E−08	0.0062	DNAJC17	Body
cg14789911	21	47582049	0.65	0.43	0.22	1.25E−06	0.0411	C21orf56	Body
cg03311906	22	20376405	0.77	0.57	0.20	5.23E−07	0.0273	–	–
cg15242686	22	24348715	0.39	0.50	− 0.11	3.45E−07	0.0211	GSTTP1	TSS1500
cg04234412	22	24373322	0.49	0.32	0.17	1.31E−08	0.0028	LOC391322	Body
cg01238044	22	24384105	0.30	0.17	0.13	6.40E−07	0.0273	GSTT1	Body
cg17005068	22	24384525	0.51	0.34	0.18	3.95E−08	0.0056	GSTT1	TSS1500

^aFrom UCSC annotations. Chr Chromosome, Pos position, MS multiple sclerosis, ctr non-neurological controls, Δβ delta β-value, adj. P val adjusted P value, TSS transcription starting site

ISSN: 1868-7083