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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact

Fig. 4

Restoration of miR-340-5p in HMCLs. a By qRT-PCR, miR-340-5p was shown to be successfully overexpressed in KMS-12-PE, WL-2, and RPMI-8226R cells. By MTS assay, overexpression of miR-340-5p significantly inhibited cellular proliferation in all three cell lines. b By trypan blue staining, overexpression of miR-340-5p increased the number of dead cells by 3.73% in WL-2 cells. Error bars represent the standard deviation from three independent transfections. c By annexin V/PI analysis, overexpression of miR-340-5p increased cellular apoptosis by 9.60% in WL-2 cells

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