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Table 4 Association between ZBTB12 CpG-specific methylation and blood cell functional parameters

From: ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort

Factor n. CpG n. Coagulation time TNFɑ-stim. coagulation time Delta coag. time (basal-TNF) Platelet–monocyte aggregates Platelet–PMN aggregates
Beta SE p Beta SE p Beta SE p Beta SE p Beta SE p
F1 3–4 0.018 0.045 0.690 − 0.019 0.050 0.711 − 0.040 0.049 0.411 0.074 0.039 0.061 0.006 0.043 0.898
26 − 0.007 0.044 0.877 − 0.052 0.049 0.286 − 0.062 0.048 0.201 0.097 0.039 0.013 − 0.003 0.043 0.942
1 0.023 0.045 0.608 0.038 0.049 0.447 − 0.002 0.048 0.974 0.055 0.039 0.164 − 0.023 0.043 0.602
11 0.109 0.046 0.018 0.074 0.051 0.148 − 0.063 0.051 0.218 0.016 0.041 0.703 − 0.016 0.046 0.735
5 − 0.031 0.046 0.501 0.013 0.050 0.798 0.066 0.049 0.179 0.068 0.042 0.102 0.067 0.046 0.142
27 − 0.040 0.047 0.402 − 0.017 0.052 0.743 0.020 0.052 0.704 0.087 0.042 0.040 0.041 0.046 0.366
18–20 0.033 0.044 0.461 0.045 0.048 0.353 − 0.005 0.048 0.912 0.037 0.039 0.342 0.030 0.044 0.496
6 − 0.043 0.044 0.331 − 0.063 0.048 0.191 − 0.004 0.047 0.932 0.026 0.039 0.502 − 0.052 0.043 0.227
F2 9–10 0.104 0.044 0.018 0.154 0.048 0.002* 0.052 0.048 0.274 0.028 0.039 0.478 0.003 0.043 0.951
21 0.030 0.046 0.505 0.045 0.050 0.368 0.014 0.049 0.771 0.036 0.040 0.369 − 0.008 0.044 0.863
16 0.052 0.043 0.224 0.134 0.047 0.005* 0.106 0.046 0.023 − 0.012 0.038 0.757 − 0.010 0.043 0.820
8 0.075 0.044 0.091 0.126 0.048 0.010* 0.061 0.047 0.197 0.031 0.040 0.438 0.019 0.044 0.669
  7§ − 0.008 0.046 0.859 − 0.069 0.050 0.169 − 0.086 0.046 0.062 − 0.050 0.041 0.230 − 0.039 0.044 0.380
  1. Model adjusted by age, gender, and smoking as fixed effects and family stratification as a random effect; additional covariates were added to the model and were associated to both methylation factors and phenotypes (for blood cell counts, alcohol, and obesity). Standardized values of phenotypes and methylation are reported (beta values reported as standard deviation units). Significant p values are shown in italics
  2. *pFDR significant
  3. §Factor loading for both Factor 1 and 2 lower than 0.40