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Table 1 EC50 inhibition data of MC3353 against the enzymatic activity of human DNMT1 and human DNMT3A through radioactivity and fluorescent assay, respectively [18, 25]

From: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

Compound

EC50 ± SD, μM

hDNMT1

hDNMT3A

MC3353

67 ± 4

17 ± 3

RG-108

390 ± 50

> 500

SGI-1027

12 ± 2

0.8 ± 0.2

  1. EC50 are reported as the median concentration, at which a compound inhibits 50% of the DNA methylation and the standard deviation (SD) of at least two independent experiments for DNMT1 and DNMT3A
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Clinical Epigenetics

ISSN: 1868-7083

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