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Table 1 EC50 inhibition data of MC3353 against the enzymatic activity of human DNMT1 and human DNMT3A through radioactivity and fluorescent assay, respectively [18, 25]

From: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

Compound EC50 ± SD, μM
hDNMT1 hDNMT3A
MC3353 67 ± 4 17 ± 3
RG-108 390 ± 50 > 500
SGI-1027 12 ± 2 0.8 ± 0.2
  1. EC50 are reported as the median concentration, at which a compound inhibits 50% of the DNA methylation and the standard deviation (SD) of at least two independent experiments for DNMT1 and DNMT3A