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Table 2 Differentially methylated CpGs in umbilical cord blood DNA associated with prenatal maternal antidepressants in pregnancy

From: Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood

CpG

Chr

Genomic Position

Gene

Discovery cohort Project Viva (n = 479)

 

Replication cohort Generation R Study (n = 999c)

Mean (SD) %-DNA methylation

Adjusted % change in DNA methylation (95% CI)a

P

Mean (SD) %-DNA methylation

Adjusted % change in DNA methylation (95% CI)b

P

cg00367463

1

45,249,899

BEST4

1.9 (0.4)

0.26 (0.16, 0.37)

2.01 × 10−8

10.3 (2.7)

− 0.53 (− 1.02, − 0.03)

0.04

cg27566858

1

208,084,099

CD34

2.0 (0.3)

0.27 (0.15, 0.39)

3.13 × 10−9

12.6 (3.3)

0.26 (− 0.53, 1.06)

0.52

cg03536711

1

221,509,067

LOC400804

53.3 (11.4)

− 11.63 (− 15.80, −7.45)

3.24 × 10−8

54.9 (9.3)

2.25 (− 1.53, 6.02)

0.24

cg07729367

3

128,479,008

RAB7A

98.2 (0.5)

− 0.49 (− 0.70, − 0.27)

1.08 × 10−7

90.6 (2.1)

− 0.31 (− 1.36, 0.75)

0.57

cg22065513

3

144,241,532

 

97.1 (1.4)

− 1.22 (− 1.73, − 0.72)

4.11 × 10−9

90.7 (2.0)

− 0.36 (− 1.33, 0.61)

0.47

cg27299660

3

171,527,797

PLD1

1.7 (0.4)

0.77 (0.49, 1.04)

1.19 × 10−7

8.3 (2.3)

0.11 (− 0.55, 0.77)

0.75

cg14499053

7

19,158,954

 

2.2 (0.5)

− 0.33 (− 0.45, − 0.22)

5.44 × 10−8

11.5 (2.1)

0.35 (− 0.48, 1.19)

0.41

cg15881597

7

73,085,754

VPS37D

40.1 (4.9)

− 3.64 (− 5.09, − 2.19)

5.66 × 10−9

47.3 (4.7)

− 1.82 (− 4.06, 0.42)

0.11

cg06645921

12

8,025,394

SLC2A14

6.6 (3.7)

− 2.38 (− 2.95, − 1.81)

9.11 × 10−16

NA

NA

NA

cg27161197

12

47,224,649

 

71.5 (5.9)

− 5.17 (− 7.12, − 3.23)

1.77 × 10−9

68.9 (5.5)

− 2.01 (− 5.23, 1.21)

0.22

cg25121621

15

45,926,780

SQRDL

19.6 (2.9)

2.74 (1.82, 3.67)

2.71 × 10−12

28.4 (4.2)

− 0.80 (− 4.37, 2.78)

0.66

cg06358612

17

28,619,293

BLMH

1.4 (0.3)

0.22 (0.14, 0.31)

6.07 × 10−8

8.1 (1.4)

− 0.18 (− 0.71, 0.34)

0.49

cg22159528

19

44,039,727

ZNF575

51.0 (6.8)

− 7.23 (− 10.36, − 4.10)

1.03 × 10 −8

54.7 (5.9)

− 2.46 (− 4.23, − 0.69)

0.006

cg12489353

19

48,231,499

EHD2

79.3 (14.5)

− 10 (− 15.7, − 4.3)

7.88 × 10−8

77.2 (10)

− 0.80 (− 6.49, 4.88)

0.78

cg11449935

20

35,202,477

TGIF2

2.2 (0.4)

0.29 (0.16, 0.43)

4.20 × 10−8

10.2 (2.2)

0.31(− 0.52, 1.13)

0.47

cg18036763

22

45,404,910

PHF21B

10.2 (3.6)

3.24 (1.75, 4.74)

7.62 × 10−8

6.2 (1.7)

0.38 (− 0.34, 1.11)

0.30

  1. Abbreviations: SD standard deviation, CI confidence interval, NA excluded from the replication cohort (Generation R Study) after standard quality control
  2. aAdjusted for maternal age, parity, race/ethnicity, smoking (never, former and during pregnancy), pre-pregnancy BMI, mode of delivery, education and infant sex, gestational age, and estimated cord blood nucleated cells (CD8, CD4, Mono, NK, B cells, granulocytes and nRBCs)
  3. bAdjusted for the same covariates as above and included sample plate as an additional covariate
  4. cRefers to sample size for cg22159528, whereas other models from Generation R Study excluded samples that failed at specific CpG sites (smallest sample size n = 970 for cg18036763)
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Clinical Epigenetics

ISSN: 1868-7083

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