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Table 2 Differentially methylated CpGs in umbilical cord blood DNA associated with prenatal maternal antidepressants in pregnancy

From: Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood

CpG Chr Genomic Position Gene Discovery cohort Project Viva (n = 479)   Replication cohort Generation R Study (n = 999c)
Mean (SD) %-DNA methylation Adjusted % change in DNA methylation (95% CI)a P Mean (SD) %-DNA methylation Adjusted % change in DNA methylation (95% CI)b P
cg00367463 1 45,249,899 BEST4 1.9 (0.4) 0.26 (0.16, 0.37) 2.01 × 10−8 10.3 (2.7) − 0.53 (− 1.02, − 0.03) 0.04
cg27566858 1 208,084,099 CD34 2.0 (0.3) 0.27 (0.15, 0.39) 3.13 × 10−9 12.6 (3.3) 0.26 (− 0.53, 1.06) 0.52
cg03536711 1 221,509,067 LOC400804 53.3 (11.4) − 11.63 (− 15.80, −7.45) 3.24 × 10−8 54.9 (9.3) 2.25 (− 1.53, 6.02) 0.24
cg07729367 3 128,479,008 RAB7A 98.2 (0.5) − 0.49 (− 0.70, − 0.27) 1.08 × 10−7 90.6 (2.1) − 0.31 (− 1.36, 0.75) 0.57
cg22065513 3 144,241,532   97.1 (1.4) − 1.22 (− 1.73, − 0.72) 4.11 × 10−9 90.7 (2.0) − 0.36 (− 1.33, 0.61) 0.47
cg27299660 3 171,527,797 PLD1 1.7 (0.4) 0.77 (0.49, 1.04) 1.19 × 10−7 8.3 (2.3) 0.11 (− 0.55, 0.77) 0.75
cg14499053 7 19,158,954   2.2 (0.5) − 0.33 (− 0.45, − 0.22) 5.44 × 10−8 11.5 (2.1) 0.35 (− 0.48, 1.19) 0.41
cg15881597 7 73,085,754 VPS37D 40.1 (4.9) − 3.64 (− 5.09, − 2.19) 5.66 × 10−9 47.3 (4.7) − 1.82 (− 4.06, 0.42) 0.11
cg06645921 12 8,025,394 SLC2A14 6.6 (3.7) − 2.38 (− 2.95, − 1.81) 9.11 × 10−16 NA NA NA
cg27161197 12 47,224,649   71.5 (5.9) − 5.17 (− 7.12, − 3.23) 1.77 × 10−9 68.9 (5.5) − 2.01 (− 5.23, 1.21) 0.22
cg25121621 15 45,926,780 SQRDL 19.6 (2.9) 2.74 (1.82, 3.67) 2.71 × 10−12 28.4 (4.2) − 0.80 (− 4.37, 2.78) 0.66
cg06358612 17 28,619,293 BLMH 1.4 (0.3) 0.22 (0.14, 0.31) 6.07 × 10−8 8.1 (1.4) − 0.18 (− 0.71, 0.34) 0.49
cg22159528 19 44,039,727 ZNF575 51.0 (6.8) − 7.23 (− 10.36, − 4.10) 1.03 × 10 −8 54.7 (5.9) − 2.46 (− 4.23, − 0.69) 0.006
cg12489353 19 48,231,499 EHD2 79.3 (14.5) − 10 (− 15.7, − 4.3) 7.88 × 10−8 77.2 (10) − 0.80 (− 6.49, 4.88) 0.78
cg11449935 20 35,202,477 TGIF2 2.2 (0.4) 0.29 (0.16, 0.43) 4.20 × 10−8 10.2 (2.2) 0.31(− 0.52, 1.13) 0.47
cg18036763 22 45,404,910 PHF21B 10.2 (3.6) 3.24 (1.75, 4.74) 7.62 × 10−8 6.2 (1.7) 0.38 (− 0.34, 1.11) 0.30
  1. Abbreviations: SD standard deviation, CI confidence interval, NA excluded from the replication cohort (Generation R Study) after standard quality control
  2. aAdjusted for maternal age, parity, race/ethnicity, smoking (never, former and during pregnancy), pre-pregnancy BMI, mode of delivery, education and infant sex, gestational age, and estimated cord blood nucleated cells (CD8, CD4, Mono, NK, B cells, granulocytes and nRBCs)
  3. bAdjusted for the same covariates as above and included sample plate as an additional covariate
  4. cRefers to sample size for cg22159528, whereas other models from Generation R Study excluded samples that failed at specific CpG sites (smallest sample size n = 970 for cg18036763)