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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets

Fig. 1

Enrichment of dcSSc differentially methylated CpGs in DNase I hypersensitive sites among various cell and tissue types using ENCODE, Roadmap Epigenomics, and BLUEPRINT Epigenome projects data. Statistically significant enrichment outside the 99.9th percentile (−log10 binomial p value ≥ 3.38) is colored red on the vertical axis. Upper panel shows a marked myeloid cell enrichment in ENCODE data, with strong epithelium, heart, muscle, blood vessel, and connective tissue signals. Middle panel shows a more general pattern of enrichment, strongest in blood, fetal tissues, and psoas muscle in the Roadmap Epigenomics data. Lower panel shows enrichment for inflammatory macrophages in the BLUEPRINT Epigenome data

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Clinical Epigenetics

ISSN: 1868-7083

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