|
CpG location
|
Tumor vs normal1
|
Recurrence1
|
Stage1
|
Gleason score (overall)2
|
GS6 vs GS8 +3
|
GS7a vs GS8 +3
|
GS7b vs GS8 +3
|
GS6 vs normal3
|
GS7a vs normal3
|
GS7b vs normal3
|
GS8+ vs normal3
|
|---|
| |
ASB2 (chr14)
|
|
94423399
|
5.3192E−04***
|
0.2409
|
0.9747
|
1.2538E−04***
|
1
|
0.1919
|
1
|
0.0416*
|
0.0151*
|
5.4253E−04***
|
2.6764E−05***
|
|
94423704
|
5.4896E−07***
|
0.702
|
0.658
|
1.9181E−12***
|
1
|
0.258
|
1
|
1.0501E−04***
|
1.4758E−08***
|
1.8719E−10***
|
6.6097E−13***
|
|
94424156
|
0.0011**
|
0.7441
|
0.1885
|
1.6348E−06***
|
1
|
0.496
|
1
|
0.0481*
|
5.4625E−04***
|
1.5358E−06***
|
1.5159E−06***
|
| |
ETNK2 (chr1)
|
|
204121503
|
0.0012**
|
0.0306*
|
0.4185
|
1.3158E−12***
|
0.0431*
|
2.2029E−05***
|
0.2733
|
0.0150*
|
3.8371E−04***
|
4.8206E−07***
|
3.5387E−13***
|
|
204121899
|
0.00017425***
|
0.0618
|
0.0142*
|
6.6353E−06***
|
0.7984
|
9.3204E−04***
|
1
|
0.1681
|
0.3024
|
0.0013**
|
9.6444E−06***
|
|
204121923
|
1.0324E−08***
|
0.2862
|
0.0518
|
3.5270E−10***
|
1
|
0.1555
|
1
|
3.4274E−04***
|
2.0944E−06***
|
1.0047E−08***
|
1.0578E−10***
|
|
204121925
|
3.4330E−07***
|
0.0649
|
0.0044**
|
7.8498E−11***
|
1
|
0.0048**
|
1
|
2.4590E−04***
|
8.0568E−05***
|
2.0361E−08***
|
3.9094E−11***
|
| |
MEIS2 (chr15)
|
|
37389951
|
1.0768E−09***
|
0.133
|
0.0183*
|
2.7510E−16***
|
1
|
0.3942
|
0.4735
|
3.4941E−07***
|
1.2511E−12***
|
2.1070E−10***
|
2.9902E−17***
|
|
37390176
|
3.9592E−12***
|
0.1417
|
0.0437*
|
6.0747E−20***
|
0.7401
|
0.1042
|
0.3351
|
1.5444E−07***
|
1.7809E−14***
|
8.8326E−13***
|
3.6691E−21***
|
|
37390284
|
5.5646E−12***
|
0.6529
|
0.0347*
|
2.1732E−18***
|
1
|
0.4868
|
0.4465
|
2.7653E−08***
|
1.7689E−14***
|
1.2108E−11***
|
4.3682E−19***
|
|
37390326
|
1.7682E−10***
|
0.9925
|
0.0507
|
1.0213E−15***
|
1
|
1
|
1
|
1.7273E−06***
|
3.7762E−14***
|
1.0088E−11***
|
3.4463E−15***
|
|
37390666
|
9.9208E−12***
|
0.781
|
0.4833
|
1.2698E−14***
|
1
|
1
|
1
|
9.1587E−06***
|
1.2821E−13***
|
2.0310E−11***
|
1.1459E−13***
|
| |
NRG1 (chr8)
|
|
31496966
|
8.6752E−10***
|
0.6985
|
0.0150*
|
2.5631E−14***
|
1
|
1
|
1
|
1.9238E−04***
|
1.2260E−14***
|
1.8753E−10***
|
4.0103E−12***
|
|
31497042
|
5.0501E−12***
|
0.0647
|
0.0319*
|
2.2705E−19***
|
1
|
0.2969
|
1
|
2.0176E−08***
|
2.0255E−14***
|
3.9698E−14***
|
9.9203E−20***
|
|
31497082
|
4.0886E−11***
|
0.0448*
|
0.0057**
|
2.1494E−17***
|
1
|
0.5099
|
1
|
6.7545E−07***
|
1.7471E–13***
|
8.9222E−13***
|
7.0663E−18***
|
|
31497464
|
1.4066E−12***
|
0.0578
|
0.0021**
|
6.4985E−19***
|
1
|
1
|
1
|
1.1607E−07***
|
8.3519E−17***
|
1.7644E−12***
|
1.4988E−18***
|
|
31498006
|
9.9208E−12***
|
0.2202
|
0.0025**
|
1.1949E−17***
|
0.1303
|
1
|
1
|
2.4495E−04***
|
6.1828E−14***
|
2.4410E−14***
|
8.2690E−17***
|
| |
NTN1 (chr17)
|
|
8924093
|
1.6691E−13***
|
0.0165*
|
0.3672
|
2.4340E−21***
|
0.205
|
0.0761
|
1
|
1.9637E−06***
|
1.6375E−14***
|
2.2252E−16***
|
1.3727E−21***
|
|
8924309
|
1.0069E−07***
|
0.3684
|
0.3741
|
8.9654E−04***
|
1
|
1
|
0.6196
|
1
|
0.0044**
|
2.0804E−04***
|
0.0105*
|
| |
NUDT10 (chrX)
|
|
51074836
|
4.7839E−06***
|
0.2173
|
0.1356
|
0.0016**
|
1
|
1
|
1
|
0.0108*
|
0.0031**
|
7.0332E−04***
|
0.0098**
|
|
51074936
|
1.8063E−06***
|
0.9068
|
0.985
|
9.0493E−07***
|
1
|
1
|
1
|
0.0023**
|
1.3634E−05***
|
8.6805E−06***
|
1.8934E−07***
|
|
51074953
|
0.0140*
|
0.8895
|
0.7916
|
0.2201
|
1
|
1
|
1
|
0.5458
|
0.1431
|
0.3771
|
0.1566
|
|
51075046
|
8.3171E−06***
|
0.9564
|
0.1815
|
1.1351E−05***
|
1
|
0.4569
|
1
|
0.0936
|
0.0082**
|
3.7804E−06***
|
4.5893E−05***
|
|
51075126
|
3.3740E−05***
|
0.2602
|
0.4731
|
7.1943E−06***
|
0.9654
|
1
|
0.0695
|
0.0017**
|
2.2205E−04***
|
1.3429E−06***
|
0.0035**
|
|
51075273
|
0.0020**
|
0.9452
|
0.6984
|
0.0230*
|
1
|
1
|
0.1072
|
1
|
1
|
*0.0217
|
1
|
|
51075797
|
0.0244*
|
0.8575
|
0.3457
|
0.275
|
1
|
1
|
1
|
0.4945
|
0.2262
|
0.3023
|
0.2772
|
|
51076119
|
0.0022**
|
0.0123*
|
0.0065**
|
6.5620E−09***
|
0.6303
|
3.5148E−05***
|
0.1189
|
0.0123*
|
0.0322*
|
5.7175E−04***
|
3.0404E−09***
|
| |
SRPX (chrX)
|
|
38080219
|
0.0253*
|
0.5836
|
0.2111
|
3.8518E−09***
|
1
|
8.1850E−04***
|
0.076
|
0.0022**
|
0.0013**
|
2.4744E−04***
|
2.8109E−10***
|
|
38080303
|
6.5280E−14***
|
0.3153
|
0.0722
|
3.5526E−19***
|
0.1348
|
0.3735
|
1
|
4.2450E−05***
|
5.8355E−14***
|
2.3822E−15***
|
7.1231E−19***
|
|
38080327
|
4.5130E−14***
|
0.1105
|
0.0488*
|
1.6149E−21***
|
0.1261
|
0.05907
|
1
|
2.8937E−06***
|
9.2431E−15***
|
1.4417E−15***
|
3.4189E−22***
|
|
38080364
|
1.5537E−12***
|
0.0242*
|
0.1777
|
1.8382E−19***
|
0.2859
|
0.2103
|
1
|
4.3763E−06***
|
3.3823E−14***
|
1.6902E−14***
|
6.1925E−20***
|
|
38080412
|
2.6758E−12***
|
0.9925
|
0.0321*
|
3.0305E−19***
|
0.2321
|
0.0186*
|
1
|
5.9957E−06***
|
4.7647E−12***
|
2.7680E−14***
|
4.8523E−20***
|
|
38080425
|
5.4179E−13***
|
0.9117
|
0.0162*
|
5.9541E−19***
|
0.3035
|
0.1457
|
1
|
1.0253E−05***
|
6.8240E−13***
|
1.7779E−15***
|
7.6889E−19***
|
- p values derived from 1Mann-Whitney U test, 2Kruskal-Wallis test, and 3Bonferroni-adjusted Dunn test
- Statistical significance indicated by asterisks: *0.01 < p < 0.05; **0.001 < p < 0.01; ***p < 0.001
- NA values for Dunn tests indicate lack of significance for Kruskal-Wallis test
