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Table 4 Significant changes in TET2-target gene methylation associated with prostate tumor development and progression

From: Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

CpG location

Tumor vs normal1

Recurrence1

Stage1

Gleason score (overall)2

GS6 vs GS8 +3

GS7a vs GS8 +3

GS7b vs GS8 +3

GS6 vs normal3

GS7a vs normal3

GS7b vs normal3

GS8+ vs normal3

 

ASB2 (chr14)

94423399

5.3192E−04***

0.2409

0.9747

1.2538E−04***

1

0.1919

1

0.0416*

0.0151*

5.4253E−04***

2.6764E−05***

94423704

5.4896E−07***

0.702

0.658

1.9181E−12***

1

0.258

1

1.0501E−04***

1.4758E−08***

1.8719E−10***

6.6097E−13***

94424156

0.0011**

0.7441

0.1885

1.6348E−06***

1

0.496

1

0.0481*

5.4625E−04***

1.5358E−06***

1.5159E−06***

 

ETNK2 (chr1)

204121503

0.0012**

0.0306*

0.4185

1.3158E−12***

0.0431*

2.2029E−05***

0.2733

0.0150*

3.8371E−04***

4.8206E−07***

3.5387E−13***

204121899

0.00017425***

0.0618

0.0142*

6.6353E−06***

0.7984

9.3204E−04***

1

0.1681

0.3024

0.0013**

9.6444E−06***

204121923

1.0324E−08***

0.2862

0.0518

3.5270E−10***

1

0.1555

1

3.4274E−04***

2.0944E−06***

1.0047E−08***

1.0578E−10***

204121925

3.4330E−07***

0.0649

0.0044**

7.8498E−11***

1

0.0048**

1

2.4590E−04***

8.0568E−05***

2.0361E−08***

3.9094E−11***

 

MEIS2 (chr15)

37389951

1.0768E−09***

0.133

0.0183*

2.7510E−16***

1

0.3942

0.4735

3.4941E−07***

1.2511E−12***

2.1070E−10***

2.9902E−17***

37390176

3.9592E−12***

0.1417

0.0437*

6.0747E−20***

0.7401

0.1042

0.3351

1.5444E−07***

1.7809E−14***

8.8326E−13***

3.6691E−21***

37390284

5.5646E−12***

0.6529

0.0347*

2.1732E−18***

1

0.4868

0.4465

2.7653E−08***

1.7689E−14***

1.2108E−11***

4.3682E−19***

37390326

1.7682E−10***

0.9925

0.0507

1.0213E−15***

1

1

1

1.7273E−06***

3.7762E−14***

1.0088E−11***

3.4463E−15***

37390666

9.9208E−12***

0.781

0.4833

1.2698E−14***

1

1

1

9.1587E−06***

1.2821E−13***

2.0310E−11***

1.1459E−13***

 

NRG1 (chr8)

31496966

8.6752E−10***

0.6985

0.0150*

2.5631E−14***

1

1

1

1.9238E−04***

1.2260E−14***

1.8753E−10***

4.0103E−12***

31497042

5.0501E−12***

0.0647

0.0319*

2.2705E−19***

1

0.2969

1

2.0176E−08***

2.0255E−14***

3.9698E−14***

9.9203E−20***

31497082

4.0886E−11***

0.0448*

0.0057**

2.1494E−17***

1

0.5099

1

6.7545E−07***

1.7471E–13***

8.9222E−13***

7.0663E−18***

31497464

1.4066E−12***

0.0578

0.0021**

6.4985E−19***

1

1

1

1.1607E−07***

8.3519E−17***

1.7644E−12***

1.4988E−18***

31498006

9.9208E−12***

0.2202

0.0025**

1.1949E−17***

0.1303

1

1

2.4495E−04***

6.1828E−14***

2.4410E−14***

8.2690E−17***

 

NTN1 (chr17)

8924093

1.6691E−13***

0.0165*

0.3672

2.4340E−21***

0.205

0.0761

1

1.9637E−06***

1.6375E−14***

2.2252E−16***

1.3727E−21***

8924309

1.0069E−07***

0.3684

0.3741

8.9654E−04***

1

1

0.6196

1

0.0044**

2.0804E−04***

0.0105*

 

NUDT10 (chrX)

51074836

4.7839E−06***

0.2173

0.1356

0.0016**

1

1

1

0.0108*

0.0031**

7.0332E−04***

0.0098**

51074936

1.8063E−06***

0.9068

0.985

9.0493E−07***

1

1

1

0.0023**

1.3634E−05***

8.6805E−06***

1.8934E−07***

51074953

0.0140*

0.8895

0.7916

0.2201

1

1

1

0.5458

0.1431

0.3771

0.1566

51075046

8.3171E−06***

0.9564

0.1815

1.1351E−05***

1

0.4569

1

0.0936

0.0082**

3.7804E−06***

4.5893E−05***

51075126

3.3740E−05***

0.2602

0.4731

7.1943E−06***

0.9654

1

0.0695

0.0017**

2.2205E−04***

1.3429E−06***

0.0035**

51075273

0.0020**

0.9452

0.6984

0.0230*

1

1

0.1072

1

1

*0.0217

1

51075797

0.0244*

0.8575

0.3457

0.275

1

1

1

0.4945

0.2262

0.3023

0.2772

51076119

0.0022**

0.0123*

0.0065**

6.5620E−09***

0.6303

3.5148E−05***

0.1189

0.0123*

0.0322*

5.7175E−04***

3.0404E−09***

 

SRPX (chrX)

38080219

0.0253*

0.5836

0.2111

3.8518E−09***

1

8.1850E−04***

0.076

0.0022**

0.0013**

2.4744E−04***

2.8109E−10***

38080303

6.5280E−14***

0.3153

0.0722

3.5526E−19***

0.1348

0.3735

1

4.2450E−05***

5.8355E−14***

2.3822E−15***

7.1231E−19***

38080327

4.5130E−14***

0.1105

0.0488*

1.6149E−21***

0.1261

0.05907

1

2.8937E−06***

9.2431E−15***

1.4417E−15***

3.4189E−22***

38080364

1.5537E−12***

0.0242*

0.1777

1.8382E−19***

0.2859

0.2103

1

4.3763E−06***

3.3823E−14***

1.6902E−14***

6.1925E−20***

38080412

2.6758E−12***

0.9925

0.0321*

3.0305E−19***

0.2321

0.0186*

1

5.9957E−06***

4.7647E−12***

2.7680E−14***

4.8523E−20***

38080425

5.4179E−13***

0.9117

0.0162*

5.9541E−19***

0.3035

0.1457

1

1.0253E−05***

6.8240E−13***

1.7779E−15***

7.6889E−19***

  1. p values derived from 1Mann-Whitney U test, 2Kruskal-Wallis test, and 3Bonferroni-adjusted Dunn test
  2. Statistical significance indicated by asterisks: *0.01 < p < 0.05; **0.001 < p < 0.01; ***p < 0.001
  3. NA values for Dunn tests indicate lack of significance for Kruskal-Wallis test