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Table 4 Significant changes in TET2-target gene methylation associated with prostate tumor development and progression

From: Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

CpG location Tumor vs normal1 Recurrence1 Stage1 Gleason score (overall)2 GS6 vs GS8 +3 GS7a vs GS8 +3 GS7b vs GS8 +3 GS6 vs normal3 GS7a vs normal3 GS7b vs normal3 GS8+ vs normal3
  ASB2 (chr14)
94423399 5.3192E−04*** 0.2409 0.9747 1.2538E−04*** 1 0.1919 1 0.0416* 0.0151* 5.4253E−04*** 2.6764E−05***
94423704 5.4896E−07*** 0.702 0.658 1.9181E−12*** 1 0.258 1 1.0501E−04*** 1.4758E−08*** 1.8719E−10*** 6.6097E−13***
94424156 0.0011** 0.7441 0.1885 1.6348E−06*** 1 0.496 1 0.0481* 5.4625E−04*** 1.5358E−06*** 1.5159E−06***
  ETNK2 (chr1)
204121503 0.0012** 0.0306* 0.4185 1.3158E−12*** 0.0431* 2.2029E−05*** 0.2733 0.0150* 3.8371E−04*** 4.8206E−07*** 3.5387E−13***
204121899 0.00017425*** 0.0618 0.0142* 6.6353E−06*** 0.7984 9.3204E−04*** 1 0.1681 0.3024 0.0013** 9.6444E−06***
204121923 1.0324E−08*** 0.2862 0.0518 3.5270E−10*** 1 0.1555 1 3.4274E−04*** 2.0944E−06*** 1.0047E−08*** 1.0578E−10***
204121925 3.4330E−07*** 0.0649 0.0044** 7.8498E−11*** 1 0.0048** 1 2.4590E−04*** 8.0568E−05*** 2.0361E−08*** 3.9094E−11***
  MEIS2 (chr15)
37389951 1.0768E−09*** 0.133 0.0183* 2.7510E−16*** 1 0.3942 0.4735 3.4941E−07*** 1.2511E−12*** 2.1070E−10*** 2.9902E−17***
37390176 3.9592E−12*** 0.1417 0.0437* 6.0747E−20*** 0.7401 0.1042 0.3351 1.5444E−07*** 1.7809E−14*** 8.8326E−13*** 3.6691E−21***
37390284 5.5646E−12*** 0.6529 0.0347* 2.1732E−18*** 1 0.4868 0.4465 2.7653E−08*** 1.7689E−14*** 1.2108E−11*** 4.3682E−19***
37390326 1.7682E−10*** 0.9925 0.0507 1.0213E−15*** 1 1 1 1.7273E−06*** 3.7762E−14*** 1.0088E−11*** 3.4463E−15***
37390666 9.9208E−12*** 0.781 0.4833 1.2698E−14*** 1 1 1 9.1587E−06*** 1.2821E−13*** 2.0310E−11*** 1.1459E−13***
  NRG1 (chr8)
31496966 8.6752E−10*** 0.6985 0.0150* 2.5631E−14*** 1 1 1 1.9238E−04*** 1.2260E−14*** 1.8753E−10*** 4.0103E−12***
31497042 5.0501E−12*** 0.0647 0.0319* 2.2705E−19*** 1 0.2969 1 2.0176E−08*** 2.0255E−14*** 3.9698E−14*** 9.9203E−20***
31497082 4.0886E−11*** 0.0448* 0.0057** 2.1494E−17*** 1 0.5099 1 6.7545E−07*** 1.7471E–13*** 8.9222E−13*** 7.0663E−18***
31497464 1.4066E−12*** 0.0578 0.0021** 6.4985E−19*** 1 1 1 1.1607E−07*** 8.3519E−17*** 1.7644E−12*** 1.4988E−18***
31498006 9.9208E−12*** 0.2202 0.0025** 1.1949E−17*** 0.1303 1 1 2.4495E−04*** 6.1828E−14*** 2.4410E−14*** 8.2690E−17***
  NTN1 (chr17)
8924093 1.6691E−13*** 0.0165* 0.3672 2.4340E−21*** 0.205 0.0761 1 1.9637E−06*** 1.6375E−14*** 2.2252E−16*** 1.3727E−21***
8924309 1.0069E−07*** 0.3684 0.3741 8.9654E−04*** 1 1 0.6196 1 0.0044** 2.0804E−04*** 0.0105*
  NUDT10 (chrX)
51074836 4.7839E−06*** 0.2173 0.1356 0.0016** 1 1 1 0.0108* 0.0031** 7.0332E−04*** 0.0098**
51074936 1.8063E−06*** 0.9068 0.985 9.0493E−07*** 1 1 1 0.0023** 1.3634E−05*** 8.6805E−06*** 1.8934E−07***
51074953 0.0140* 0.8895 0.7916 0.2201 1 1 1 0.5458 0.1431 0.3771 0.1566
51075046 8.3171E−06*** 0.9564 0.1815 1.1351E−05*** 1 0.4569 1 0.0936 0.0082** 3.7804E−06*** 4.5893E−05***
51075126 3.3740E−05*** 0.2602 0.4731 7.1943E−06*** 0.9654 1 0.0695 0.0017** 2.2205E−04*** 1.3429E−06*** 0.0035**
51075273 0.0020** 0.9452 0.6984 0.0230* 1 1 0.1072 1 1 *0.0217 1
51075797 0.0244* 0.8575 0.3457 0.275 1 1 1 0.4945 0.2262 0.3023 0.2772
51076119 0.0022** 0.0123* 0.0065** 6.5620E−09*** 0.6303 3.5148E−05*** 0.1189 0.0123* 0.0322* 5.7175E−04*** 3.0404E−09***
  SRPX (chrX)
38080219 0.0253* 0.5836 0.2111 3.8518E−09*** 1 8.1850E−04*** 0.076 0.0022** 0.0013** 2.4744E−04*** 2.8109E−10***
38080303 6.5280E−14*** 0.3153 0.0722 3.5526E−19*** 0.1348 0.3735 1 4.2450E−05*** 5.8355E−14*** 2.3822E−15*** 7.1231E−19***
38080327 4.5130E−14*** 0.1105 0.0488* 1.6149E−21*** 0.1261 0.05907 1 2.8937E−06*** 9.2431E−15*** 1.4417E−15*** 3.4189E−22***
38080364 1.5537E−12*** 0.0242* 0.1777 1.8382E−19*** 0.2859 0.2103 1 4.3763E−06*** 3.3823E−14*** 1.6902E−14*** 6.1925E−20***
38080412 2.6758E−12*** 0.9925 0.0321* 3.0305E−19*** 0.2321 0.0186* 1 5.9957E−06*** 4.7647E−12*** 2.7680E−14*** 4.8523E−20***
38080425 5.4179E−13*** 0.9117 0.0162* 5.9541E−19*** 0.3035 0.1457 1 1.0253E−05*** 6.8240E−13*** 1.7779E−15*** 7.6889E−19***
  1. p values derived from 1Mann-Whitney U test, 2Kruskal-Wallis test, and 3Bonferroni-adjusted Dunn test
  2. Statistical significance indicated by asterisks: *0.01 < p < 0.05; **0.001 < p < 0.01; ***p < 0.001
  3. NA values for Dunn tests indicate lack of significance for Kruskal-Wallis test
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