Skip to main content

Table 4 Gene methylation detection in plasma samples for cancer and controls

From: Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

  Sensitivity Specificity PPV NPV AUC
CA19-9 55.9% (19/34) NA NA NA NA
ADAMTS1 87.2% (34/39) 95.8% (91/95) 89/5% (34/38) 95.8% (91/96) 0.91
BNC1 64.1% (25/39) 93.7% (89/95) 80.6% (25/31) 86.4% (89/103) 0.79
ADAMTS1 and/or BNC1 97.4% (38/39) 91.6% (87/95) 82.6% (38/46) 98.9% (87/88) 0.95
ADAMTS1 and/or BNC1 and/or CA19-9 97.4% (38/39) NA NA NA NA
ADAMTS1 + CA19-9 87.2% (34/39) NA NA NA NA
BNC1 + CA19-9 89.2% (33/37) NA NA NA NA
  1. N/A: Not applicable